Dopamine fuels its own release.
Dopamine fuels its own release.
复制标题
多巴胺促进其自身释放。
DOI:
10.1038/s41593-019-0563-4
复制
发表时间:
2020
影响因子:
25
通讯作者:
Jonas,ElizabethA
中科院分区:
文献类型:
--
作者:
Chen,Rongmin;Jonas,ElizabethA
A new study shows that the enzyme monoamine oxidase funnels a byproduct of dopamine metabolism, H2O2, directly into the mitochondrial electron transport chain, stimulating ATP production. This alternative energy pathway may protect dopaminergic neurons from the toxicity induced by dopamine metabolism while supporting phasic firing.