Derivation of aortic distensibility and pulse wave velocity by image registration with a physics-based regularisation term
Derivation of aortic distensibility and pulse wave velocity by image registration with a physics-based regularisation term
复制标题
DOI：
10.1002/cnm.2589
复制
发表时间：
2014-01-01
影响因子：
2.1
通讯作者：
Hose, D. Rodney
中科院分区：
文献类型：
--
作者：
Barber, David C.;Valverde, Isra;Hose, D. Rodney
心血管系统的分析是一个固液两相密切相互作用的经典问题，也是最先进的流固相互作用(FSI)分析的丰富应用领域。在这篇论文中，我们主要研究人的大动脉。完整的FSI问题的解决需要了解墙的材料属性和关于血管支持的信息。我们表明，通过图像配准，可以从四维图像数据中获得沿主动脉的扩张性的变化。如果容器中某一点的压力数据可用，则可以将这些数据转换为绝对值。或者，可以获得沿血管的脉搏波速度值。通过将基于一维波动方程的正则化项并入配准中，提高了提取数据的质量。利用模拟数据对该方法进行了验证。对于理想的血管，可以提取膨胀度和波速的精度很高(1%-2%)。将该方法应用于6个来自轻度狭窄患者的临床数据集，结果表明，沿主动脉的波速相对恒定。版权所有(C)2013 John Wiley&Sons，Ltd.
Analysis of the cardiovascular system represents a classical problem in which the solid and fluid phases interact intimately, and so is a rich field of application for state-of-the-art fluid-solid interaction (FSI) analyses. In this paper, we focus on the human aorta. Solution of the full FSI problem requires knowledge of the material properties of the wall and information on vessel support. We show that variation of distensibility along the aorta can be obtained from four-dimensional image data using image registration. If pressure data at one point in the vessel are available, these can be converted to absolute values. Alternatively, values of pulse wave velocity along the vessel can be obtained. The quality of the extracted data is improved by the incorporation into the registration of a regularisation term based on the one-dimensional wave equation. The method has been validated using simulated data. For idealised vessels, the accuracy with which the distensibility and wave velocity can be extracted is high (1%-2%). The method is applied to six clinical datasets from patients with mild coarctation, for which it is shown that wave velocity along the aorta is relatively constant. Copyright (c) 2013 John Wiley & Sons, Ltd.