Utility of boron clusters for drug design. Hansch-fujita hydrophobic parameters pi of dicarba-closo-dodecaboranyl groups.
Utility of boron clusters for drug design. Hansch-fujita hydrophobic parameters pi of dicarba-closo-dodecaboranyl groups.
复制标题
硼簇在药物设计中的效用。
DOI：
10.1016/s0960-894x(01)00438-3
复制
发表时间：
2001
影响因子：
2.7
通讯作者：
Yasuyuki Endo
中科院分区：
文献类型：
--
作者：
Keisuke Yamamoto;Yasuyuki Endo
球形硼簇，二碳-闭-十二硼烷（碳硼烷）是一种新的疏水性药效团，与受体发生疏水相互作用。采用高效液相色谱法测定了碳硼烷基苯酚的分配系数log P，并测定了不同碳硼烷基的Hansch-Fujita疏水参数π。值（π=2.69-4.44）根据碳硼烷笼上的取代位置和异构形式（o-、m-、p-碳硼烷）而变化。这些值位于烃的值的范围内。
The spherical boron clusters, dicarba-closo-dodecaboranes (carboranes) are new hydrophobic pharmacophores, which interact hydrophobically with receptors. We have experimentally measured the partition coefficients log P for carboranylphenols employing an HPLC method, and determined the Hansch–Fujita hydrophobic parameters π of various carboranyl groups. The values (π=2.69–4.44) vary depending on the position of substitution on the carborane cage and the isomeric form (o-, m-, p-carboranes). These values lie within the range of those of hydrocarbons.