Refining the definition of hypereosinophilic syndrome
Refining the definition of hypereosinophilic syndrome
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DOI：
10.1016/j.jaci.2010.03.042
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发表时间：
2010-07-01
影响因子：
14.2
通讯作者：
Klion, Amy D.
中科院分区：
文献类型：
--
作者：
Simon, Hans-Uwe;Rothenberg, Marc E.;Klion, Amy D.
由于我们对高嗜酸性粒细胞综合征（HES）的理解的进步和新型治疗药物的可用性，定义这些疾病的原始标准正变得越来越有问题。在这里，我们讨论了目前HES定义的不足之处以及这些疾病分类的最新进展。尽管我们对某些形式的HES发病机制的理解取得了重大进展，但目前的知识水平仍不足以制定一个新的综合的HESs病因学定义。然而，我们提出了一个新的工作定义，克服了原始定义的一些最明显的局限性。[J] .中华过敏症杂志，2010;26:45-9.]
Because of advances in our understanding of the hypereosinophilic syndrome (HES) and the availability of novel therapeutic agents, the original criteria defining these disorders are becoming increasingly problematic. Here, we discuss shortcomings with the current definition of HES and recent developments in the classification of these disorders. Despite significant progress in our understanding of the pathogenesis of some forms of HES, the current state of knowledge is still insufficient to formulate a new comprehensive etiologic definition of HESs. Nevertheless, we suggest a new working definition that overcomes some of the most obvious limitations with the original definition. (J Allergy Clin Immunol 2010;126:45-9.)