Antigen-independent activation of naive and memory resting T cells by a cytokine combination.
Antigen-independent activation of naive and memory resting T cells by a cytokine combination.
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DOI：
10.1084/jem.180.3.1159
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发表时间：
1994-09-01
期刊：
影响因子：
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通讯作者：
Abrignani S
中科院分区：
文献类型：
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作者：
Unutmaz D;Pileri P;Abrignani S
我们研究了人类静息T细胞是否可以在T细胞受体占用的情况下被激活增殖并显示效应子功能。我们报道了白细胞介素2（IL-2）、肿瘤坏死因子α和IL-6的组合激活高度纯化的初始（CD 45 RA+）和记忆（CD 45 RO+）静息CD 4 + T细胞以增殖。在这种情况下，记忆静息T细胞也可以显示效应子功能，如通过淋巴因子合成测量的，并帮助B细胞产生免疫球蛋白。这种新的Ag非依赖性T细胞活化途径可能在体内招募免疫应答部位的效应T细胞和在缺乏抗原刺激的情况下维持记忆T细胞的克隆大小方面发挥重要作用。此外，细胞因子可以诱导幼稚T细胞的增殖而不转换为记忆表型，这可能有助于维持幼稚T细胞的外周池。
We investigated whether human resting T cells could be activated to proliferate and display effector function in the absence of T cell receptor occupancy. We report that combination of interleukin 2 (IL-2), tumor necrosis factor alpha, and IL-6 activated highly purified naive (CD45RA+) and memory (CD45RO+) resting CD4+ T cells to proliferate. Under this condition, memory resting T cells could also display effector function as measured by lymphokine synthesis and help for immunoglobulin production by B cells. This novel Ag-independent pathway of T cell activation may play an important role in vivo in recruiting effector T cells at the site of immune response and in maintaining the clonal size of memory T cells in the absence of antigenic stimulation. Moreover, cytokines can induce proliferation of naive T cells without switch to memory phenotype and this may help the maintenance of the peripheral pool of naive T cells.