Cigarette smoking-associated isoform switching and 3' UTR lengthening via alternative polyadenylation.
Cigarette smoking-associated isoform switching and 3' UTR lengthening via alternative polyadenylation.
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DOI：
10.1016/j.ygeno.2021.11.004
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发表时间：
2021-11
期刊：
影响因子：
4.4
通讯作者：
COPDGene Investigators
中科院分区：
文献类型：
--
作者：
Xu Z;Platig J;Lee S;Boueiz A;Chase R;Jain D;Gregory A;Suryadevara R;Berman S;Bowler R;Hersh CP;Laederach A;Castaldi PJ;COPDGene Investigators
Cigarette smoking induces a profound transcriptomic and systemic inflammatory response. Previous studies have focused on gene level differential expression of smoking, but the genome-wide effects of smoking on alternative isoform regulation have not yet been described. We conducted RNA sequencing in whole-blood samples of 454 current and 767 former smokers in the COPDGene Study, and we analyzed the effects of smoking on differential usage of isoforms and exons. At 10% FDR, we detected 3167 differentially expressed genes, 945 differentially used isoforms and 160 differentially used exons. Isoform switch analysis revealed widespread 3′ UTR lengthening associated with cigarette smoking. The lengthening of these 3′ UTRs was consistent with alternative usage of distal polyadenylation sites, and these extended 3′ UTR regions were significantly enriched with functional sequence elements including microRNA and RNA-protein binding sites. These findings warrant further studies on alternative polyadenylation events as potential biomarkers and novel therapeutic targets for smoking-related diseases.
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影响因子：
14.9
作者：
Buniello, Annalisa;MacArthur, Jacqueline A. L.;Parkinson, Helen
通讯作者：
Parkinson, Helen
影响因子：
12.3
作者：
Beane J;Sebastiani P;Liu G;Brody JS;Lenburg ME;Spira A
通讯作者：
Spira A
影响因子：
11
作者：
Erzurumluoglu AM;Liu M;Jackson VE;Barnes DR;Datta G;Melbourne CA;Young R;Batini C;Surendran P;Jiang T;Adnan SD;Afaq S;Agrawal A;Altmaier E;Antoniou AC;Asselbergs FW;Baumbach C;Bierut L;Bertelsen S;Boehnke M;Bots ML;Brazel DM;Chambers JC;Chang-Claude J;Chen C;Corley J;Chou YL;David SP;de Boer RA;de Leeuw CA;Dennis JG;Dominiczak AF;Dunning AM;Easton DF;Eaton C;Elliott P;Evangelou E;Faul JD;Foroud T;Goate A;Gong J;Grabe HJ;Haessler J;Haiman C;Hallmans G;Hammerschlag AR;Harris SE;Hattersley A;Heath A;Hsu C;Iacono WG;Kanoni S;Kapoor M;Kaprio J;Kardia SL;Karpe F;Kontto J;Kooner JS;Kooperberg C;Kuulasmaa K;Laakso M;Lai D;Langenberg C;Le N;Lettre G;Loukola A;Luan J;Madden PAF;Mangino M;Marioni RE;Marouli E;Marten J;Martin NG;McGue M;Michailidou K;Mihailov E;Moayyeri A;Moitry M;Müller-Nurasyid M;Naheed A;Nauck M;Neville MJ;Nielsen SF;North K;Perola M;Pharoah PDP;Pistis G;Polderman TJ;Posthuma D;Poulter N;Qaiser B;Rasheed A;Reiner A;Renström F;Rice J;Rohde R;Rolandsson O;Samani NJ;Samuel M;Schlessinger D;Scholte SH;Scott RA;Sever P;Shao Y;Shrine N;Smith JA;Starr JM;Stirrups K;Stram D;Stringham HM;Tachmazidou I;Tardif JC;Thompson DJ;Tindle HA;Tragante V;Trompet S;Turcot V;Tyrrell J;Vaartjes I;van der Leij AR;van der Meer P;Varga TV;Verweij N;Völzke H;Wareham NJ;Warren HR;Weir DR;Weiss S;Wetherill L;Yaghootkar H;Yavas E;Jiang Y;Chen F;Zhan X;Zhang W;Zhao W;Zhao W;Zhou K;Amouyel P;Blankenberg S;Caulfield MJ;Chowdhury R;Cucca F;Deary IJ;Deloukas P;Di Angelantonio E;Ferrario M;Ferrières J;Franks PW;Frayling TM;Frossard P;Hall IP;Hayward C;Jansson JH;Jukema JW;Kee F;Männistö S;Metspalu A;Munroe PB;Nordestgaard BG;Palmer CNA;Salomaa V;Sattar N;Spector T;Strachan DP;Understanding Society Scientific Group, EPIC-CVD, GSCAN, Consortium for Genetics of Smoking Behaviour, CHD Exome+ consortium;van der Harst P;Zeggini E;Saleheen D;Butterworth AS;Wain LV;Abecasis GR;Danesh J;Tobin MD;Vrieze S;Liu DJ;Howson JMM
通讯作者：
Howson JMM
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
11.2
作者：
Bosse, Yohan;Postma, Dirkje S.;Laviolette, Michel
通讯作者：
Laviolette, Michel