Bilateral grey-matter increase in the putamen in primary blepharospasm
Bilateral grey-matter increase in the putamen in primary blepharospasm
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DOI：
10.1136/jnnp.2005.087148
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发表时间：
2006-09-01
影响因子：
11
通讯作者：
Sander, D.
中科院分区：
文献类型：
--
作者：
Etgen, T.;Muehlau, M.;Sander, D.
背景：原发性眼睑痉挛是一种局灶性肌张力障碍，其特征是眼皮过度非自愿闭合。目的：明确与原发性眼睑痉挛相关的灰质改变。方法：对16例右利手原发性眼睑痉挛患者(平均年龄67.4(SD 4.3)岁，女性12例)与16例性别、年龄匹配的健康志愿者进行比较。每个参与者的高分辨率T1加权磁共振成像被获得，并通过基于体素的形态计量学进行分析，这是一种检测患者和对照组之间灰质区域特异性差异的方法。结果：在原发性眼睑痉挛的患者中，观察到壳质灰质的增加，而回归分析并未显示灰质的增加与原发性眼睑痉挛或肉毒神经毒素治疗(BONT)的持续时间相关。左侧顶下小叶灰质减少；灰质减少的回归分析显示灰质减少与持续时间显著相关(p=0.013)。结论：这些数据提示了原发性眼睑痉挛的结构变化，并指出壳核在该局灶性肌张力障碍的病理生理学中起着关键作用。
Background: Primary blepharospasm is a focal dystonia characterised by excessive involuntary closure of the eyelids. The pathophysiology of primary blepharospasm is unresolved.Aim: To pinpoint grey-matter changes that are associated with primary blepharospasm.Methods: 16 right-handed patients with primary blepharospasm ( mean age 67.4 ( SD 4.3) years; 12 women) were compared with 16 healthy volunteers matched for sex and age. High-resolution T1-weighted magnetic resonance imaging of each participant was obtained and analysed by voxel-based morphometry, a method to detect regionally specific differences in grey matter between patients and control group. To evaluate whether the identified grey-matter changes were correlated with the duration of primary blepharospasm or botulinum neurotoxin treatment (BoNT), separate regression analyses were carried out.Results: In patients with primary blepharospasm, grey-matter increase in the putamina was observed, whereas regression analyses did not indicate a correlation between grey- matter increases and the duration of primary blepharospasm or BoNT. Grey-matter decrease was detected in the left inferior parietal lobule; here regression analyses of grey- matter decrease showed a significant (p = 0.013) correlation of grey- matter decrease with the duration of BoNT.Conclusions: The data suggest structural changes in primary blepharospasm and point to a crucial role of the putamen for the pathophysiology of this focal dystonia.