STING, nanoparticles, autoimmune disease and cancer: a novel paradigm for immunotherapy?
STING, nanoparticles, autoimmune disease and cancer: a novel paradigm for immunotherapy?
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DOI：
10.1586/1744666x.2015.995097
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发表时间：
2015-01
影响因子：
4.4
通讯作者：
Mellor AL
中科院分区：
文献类型：
--
作者：
Lemos H;Huang L;McGaha T;Mellor AL
DNA具有强大的免疫原性，有助于提高疫苗效力。如果DNA传感不受监管，DNA还会引发超炎症和自身免疫。矛盾的是，当DNA作为DNA纳米颗粒(DNPs)全身给药时，DNA调节免疫和自身免疫。DNPs通过胞质DNA传感器激活干扰素基因的信号适配器刺激物(STING)来调节免疫。在这篇综述中，我们描述了DNA传感激活STING如何促进调节反应，并讨论了这些反应的生物学和临床意义，以了解疾病进展和设计更好的治疗慢性炎症性疾病的患者，如自身免疫综合征或癌症。
DNA has potent immunogenic properties that are useful to enhance vaccine efficacy. DNA also incites hyper-inflammation and autoimmunity if DNA sensing is not regulated. Paradoxically, DNA regulates immunity and autoimmunity when administered systemically as DNA nanoparticles (DNPs). DNPs regulated immunity via cytosolic DNA sensors that activate the signaling adaptor Stimulator of Interferon Genes (STING). In this review, we describe how DNA sensing to activate STING promotes regulatory responses and discuss the biological and clinical implications of these responses for understanding disease progression and designing better therapies for patients with chronic inflammatory diseases such as autoimmune syndromes or cancer.
影响因子：
2.6
作者：
Muñoz D;Escartín A;Dapena D;Coret F;Fernández-Uría D;Pérez D;Casanova B;Guijarro-Castro C;Munteis E;del-Campo Amigo M;Pego R;Calles C;García-Rey C;Monsalve N;Sánchez-Matienzo D
通讯作者：
Sánchez-Matienzo D