Circadian periods of single suprachiasmatic neurons in rats
Circadian periods of single suprachiasmatic neurons in rats
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DOI：
10.1016/s0304-3940(98)00464-9
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发表时间：
1998-07-10
影响因子：
2.5
通讯作者：
Honma, K
中科院分区：
文献类型：
--
作者：
Honma, S;Shirakawa, T;Honma, K
在大鼠视交叉上核（SCN）的分散细胞培养物中，通过多电极培养皿连续监测单个神经元的神经元活动超过5天。 88 个神经元中的 67 个神经元的放电率显示出强大的昼夜节律。平均昼夜节律为24.2小时，与出生当天失明的114只断奶大鼠的自主活动节律几乎相同。然而，单个SCN神经元的昼夜节律周期分散在20.0至28.3小时（SD，1.4小时）之间，而活动节律周期则集中在24.0至24.8小时（SD，0.2小时）之间。结论是大量的SCN神经元含有昼夜节律振荡器，其周期比整个SCN的昼夜节律周期变化更大。研究表明，各个视交叉上核神经元的昼夜节律能够相互同步，并整合起来构成视交叉上核内的多振荡系统。 (C) 1998 Elsevier Science ireland Ltd. 保留所有权利。
Neuronal activity of a single neuron was monitored continuously for more than 5 days by means of a multi-electrode dish in dispersed cell culture of the rat suprachiasmatic nucleus (SCN). Sixty-seven out of 88 neurons showed a robust circadian rhythm in firing rate. The mean circadian period was 24.2 h, which was almost identical to that of the locomotor activity rhythm in 114 weanling rats blinded on the day of birth. However, the circadian period in individual SCN neurons was scattered from 20.0 to 28.3 h (SD, 1.4 h), while the period of activity rhythm clustered from 24.0 to 24.8 h (SD, 0.2 h). It is concluded that a large number of SCN neurons contain the circadian oscillator, the period of which is more variable than the circadian period of the SCN as a whole. It is suggested that the circadian rhythms in individual SCN neurons are capable of synchronizing to each other and are integrated to constitute a multiple oscillator system(s) within the SCN. (C) 1998 Elsevier Science ireland Ltd. All rights reserved.