Translational coupling during expression of the tryptophan operon of Escherichia coli.
Translational coupling during expression of the tryptophan operon of Escherichia coli.
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发表时间：
1980-08
期刊：
影响因子：
3.3
通讯作者：
D. Oppenheim;C. Yanofsky
中科院分区：
文献类型：
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作者：
D. Oppenheim;C. Yanofsky
E.大肠杆菌trpE极性突变对trpD基因表达的极性是对下游（trpC、B或A）基因表达的10倍。这种效应被证明是“翻译偶联”的结果，其中trpE-trpD顺反子间标点区的有效翻译由重叠的终止密码子和起始密码子组成，并且trpE和trpD基因产物在细胞中形成功能复合物。在光的观察和特点，几种模型的平移耦合的机制被认为是。
E. coli trpE polar mutations are 10 time more polar on trpD gene expression than on downstream (trpC, B, or A) gene expression. This effects was shown to be the result of "translational coupling," in which efficient translation of trpE-trpD intercistronic punctuation region consists of overlapping stop and start codons, and the trpE and trpD gene products form a functional complex in the cell. In light observations and characteristics, several models for the mechanism of translational coupling are considered.