Effects of Luteolin on Liver, Kidney and Brain in Pentylentetrazol-Induced Seizures: Involvement of Metalloproteinases and NOS Activities
Effects of Luteolin on Liver, Kidney and Brain in Pentylentetrazol-Induced Seizures: Involvement of Metalloproteinases and NOS Activities
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DOI：
10.5152/balkanmedj.2011.030
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发表时间：
2012-01-01
影响因子：
3
通讯作者：
Uzum, Gulay
中科院分区：
文献类型：
--
作者：
Birman, Husniye;Dar, Kadriye Akgun;Uzum, Gulay
目的：黄酮类化合物是植物中一类重要的抗氧化剂。木犀草素（LUT）是植物界的一种天然黄酮类化合物。本研究旨在探讨LUT对戊四氮（PTZ）致痫大鼠肝、肾、脑组织的影响及其与一氧化氮合酶（iNOS）、内皮型一氧化氮合酶（eNOS）和基质金属蛋白酶（MMP 2、MMP 9）的关系。结果：戊四氮（PTZ）80 mg/kg腹腔注射1 h后，LUT预处理组大鼠癫痫发作次数明显减少（P
Objective: Flavonoids are an important group of recognized antioxidants in plants. Luteolin (LUT) is a natural flavonoid in the plant kingdom. This study was aimed to investigate the effects of the LUT in the liver, kidney and brain of pentylentetrazol (PTZ)-induced seizure and the relationship between nitric oxide synthases (iNOS, eNOS) and matrix metalloproteinases (MMP2, MMP9).Materials and Methods: LUT (10 mg/kg) was given intraperitoneally during two weeks prior to seizure induction. A single dose PTZ 80 mg/kg i.p. was administered and seizures were observed and evaluated with regard to latency, frequency and stage for one hour.Results: Seizure frequen cy after PTZ administration was significantly decreased in LUT pretreated rats (p