Functional magnetic resonance adaptation reveals the involvement of the dorsomedial stream in hand orientation for grasping
Functional magnetic resonance adaptation reveals the involvement of the dorsomedial stream in hand orientation for grasping
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DOI：
10.1152/jn.01069.2010
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发表时间：
2011-11-01
影响因子：
2.5
通讯作者：
Culham, Jody C.
中科院分区：
文献类型：
--
作者：
Monaco, Simona;Cavina-Pratesi, Cristiana;Culham, Jody C.
摩纳哥 S、卡维纳-普拉泰西 C、塞达 A、法托里 P、加莱蒂 C、卡勒姆 JC。功能性磁共振适应揭示了背内侧流参与抓握的手方向。 J Neurophysiol 106: 2248-2263, 2011。首次发表于 2011 年 7 月 27 日； doi:10.1152/jn.01069.2010.-伸手抓握动作需要上肢不同部分的协调。先前的研究已经检查了手臂运输和此类动作的握力成分的神经基质。然而，第三个组成部分在很大程度上被忽视了：手腕和手的方向适合物体。在这里，我们使用功能磁共振成像适应（fMRA）来研究人脑在抓握运动过程中参与处理手部方向的区域。参与者使用惯用的右手，用与拇指相对的四个手指抓住一根杆，或者用指关节触及并触摸杆，而无需视觉反馈。在控制条件下，参与者被动地观察杆。慢速事件相关设计的试验包括两个连续刺激，其中杆方向发生变化（需要在抓握但不伸手或看时改变手腕姿势）或保持不变。我们发现，当以相同方向反复抓住物体时，上顶枕皮质（SPOC）的激活（即适应）减少。相比之下，当以相同方向到达或观察物体时，没有适应，这表明手的方向，而不是物体的方向，是关键因素。这些结果与最近的神经生理学研究一致，该研究表明猕猴的顶枕区（V6A）在伸手抓握动作期间受到手部方向的调节。我们认为，人类的背内侧流，就像猕猴的背内侧流一样，在处理伸手抓握动作中的手部方向方面发挥着关键作用。
Monaco S, Cavina-Pratesi C, Sedda A, Fattori P, Galletti C, Culham JC. Functional magnetic resonance adaptation reveals the involvement of the dorsomedial stream in hand orientation for grasping. J Neurophysiol 106: 2248-2263, 2011. First published July 27, 2011; doi:10.1152/jn.01069.2010.-Reach-to-grasp actions require coordination of different segments of the upper limbs. Previous studies have examined the neural substrates of arm transport and hand grip components of such actions; however, a third component has been largely neglected: the orientation of the wrist and hand appropriately for the object. Here we used functional magnetic resonance imaging adaptation (fMRA) to investigate human brain areas involved in processing hand orientation during grasping movements. Participants used the dominant right hand to grasp a rod with the four fingers opposing the thumb or to reach and touch the rod with the knuckles without visual feedback. In a control condition, participants passively viewed the rod. Trials in a slow event-related design consisted of two sequential stimuli in which the rod orientation changed (requiring a change in wrist posture while grasping but not reaching or looking) or remained the same. We found reduced activation, that is, adaptation, in superior parieto-occipital cortex (SPOC) when the object was repeatedly grasped with the same orientation. In contrast, there was no adaptation when reaching or looking at an object in the same orientation, suggesting that hand orientation, rather than object orientation, was the critical factor. These results agree with recent neurophysiological research showing that a parieto-occipital area of macaque (V6A) is modulated by hand orientation during reach-to-grasp movements. We suggest that the human dorsomedial stream, like that in the macaque, plays a key role in processing hand orientation in reach-to-grasp movements.