High prevalence of cardiovascular risk factors in children and adolescents with type 1 diabetes: a population-based study
High prevalence of cardiovascular risk factors in children and adolescents with type 1 diabetes: a population-based study
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DOI：
10.1007/s00125-007-0921-8
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发表时间：
2008-04-01
期刊：
影响因子：
8.2
通讯作者：
Dahl-Jorgensen, K.
中科院分区：
文献类型：
--
作者：
Margeirsdottir, H. D.;Larsen, J. R.;Dahl-Jorgensen, K.
目的/假设1型糖尿病患者在40岁之前死于心血管疾病（CVD）的风险比非糖尿病患者增加近20倍。本研究的目的是评估心血管疾病的危险因素的患病率在一项以人群为基础的研究儿童和青少年与1型diabetes.Methods心血管疾病的危险因素进行了检查，根据美国糖尿病协会的标准在2005年。在挪威的26家儿科诊所中，有25家参与了该项目，共有1 658名患者，占合格患者的85%。结果71.4%的患者HbA（1c）在目标值以上，平均年龄13.1岁，平均糖尿病病程5.7年。在33%的参与者中发现了早期CVD和/或糖尿病的阳性家族史。34.5%的参与者LDL胆固醇>2.6 mmol/l，HDL胆固醇≥ 12岁，报告吸烟，所有参与者中有1%有持续性微量白蛋白尿。仅0.2%的患者接受他汀类药物治疗，0.3%的患者接受抗高血压治疗。对部分患者的饮食习惯和体力活动水平进行了评价。几乎所有人的膳食脂肪摄入量都高于建议，而纤维摄入量低于建议。很大一部分是不太活跃，看更多的电视比recommended.Conclusions/解释的参与者，86%至少有一个，45%至少有两个和15%至少有三个心血管疾病的危险因素。少数患者接受他汀类药物和抗高血压药物治疗。
Aims/hypothesis The risk of dying of cardiovascular disease (CVD) before the age of 40 years is increased nearly 20-fold in patients with type 1 diabetes compared with non-diabetic persons. The aim of this study was to evaluate the prevalence of CVD risk factors in a population-based study of children and adolescents with type 1 diabetes.Methods CVD risk factors were examined according to the American Diabetes Association criteria in 2005. Of 26 paediatric clinics in Norway, 25 participated with 1,658 patients, 85% of those eligible. Mean age was 13.1 years and mean diabetes duration 5.7 years.Results HbA(1c) was above the target level in 71.4%. A positive family history of early CVD and/or diabetes was found in 33% of participants. LDL-cholesterol was >2.6 mmol/l in 34.5% and HDL-cholesterol was = 12 years of age reported smoking and 1% of all participants had persistent microalbuminuria. Only 0.2% of the patients were receiving statin and 0.3% anti-hypertensive treatments. Dietary habits and physical activity level were evaluated in some patients. Almost all had higher intake of dietary fat and lower intake of fibre than recommended. A large part was less active and watched more TV than recommended.Conclusions/interpretation Of the participants, 86% had at least one, 45% at least two and 15% at least three CVD risk factors. Few patients were treated with statins and anti-hypertensive drugs.