Epithelial coating controls mesenchymal shape change through tissue-positioning effects and reduction of surface-minimizing tension
Epithelial coating controls mesenchymal shape change through tissue-positioning effects and reduction of surface-minimizing tension
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DOI：
10.1038/ncb1669
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发表时间：
2008-01-01
影响因子：
21.3
通讯作者：
Winklbauer, Rudolf
中科院分区：
文献类型：
--
作者：
Ninomiya, Hiromasa;Winklbauer, Rudolf
间充质细胞和上皮细胞之间的信号传导对器官形态发生具有深远的影响。然而，很少有人知道上皮间质相互作用的机械功能。在这里，我们描述了两个主要的影响，上皮细胞可以调节间充质细胞聚集体的形状变化。我们提出，在胚胎体轴的形成过程中，上皮层减轻表面张力，使其最小化，从而迫使细胞聚集成球形，并控制细胞群沿轴沿着的连续排列。组合效应允许组织偏离球形并伸长。
signalling between mesenchymal and epithelial cells has a profound influence on organ morphogenesis. However, less is known about the mechanical function of epithelial mesenchymal interactions. Here, we describe two principal effects by which epithelia can regulate shape changes in mesenchymal cell aggregates. We propose that during formation of the embryonic body axis, the epithelial layer relieves surface minimizing tensions that would force cell aggregates into a spherical shape, and controls the serial arrangement of cell populations along the axis. the combined effects permit the tissue to deviate from a spherical form and to elongate.