Deletion of specific sequences or modification of centromeric chromatin are responsible for Y chromosome centromere inactivation
Deletion of specific sequences or modification of centromeric chromatin are responsible for Y chromosome centromere inactivation
复制标题
特定序列的缺失或着丝粒染色质的修饰导致 Y 染色体着丝粒失活
作者：
P. Maraschio;O. Zuffardi;A. Caiulo;E. Dainotti;M. Piantanida;H. Rivera;R. Tupler
SummaryStable dicentric chromosomes behave as monocentrics because one of the centromeres is inactive. The cause of centromere inactivation is unknown; changes in centromere chromatin conformation and loss of centromeric DNA elements have been proposed as possible mechanisms. We studied the phenomenon of inactivation in two Y centromeres, having as a control genetically identical active Y centromeres. The two cases have the following karyotypes: 45,X/46,X,i(Y)(q12) and 46,XY/ 47,XY,+t(X;Y)(p22.3;p11.3). The analysis of the behaviour of the active and inactive Y chromosome centromeres after Da-Dapi staining, CREST immunofluorescence, and in situ hybridization with centromeric probes leads us to conclude that, in the case of the isochromosome, a true deletion of centromeric chromatin is responsible for its stability, whereas in the second case, stability of the dicentric (X;Y) is the result of centromere chromatin modification.
通过 alphoid DNA 序列表征特定染色体的人类着丝粒区域。
影响因子：
9.8
作者：
Jabs,EW;Persico,MG
通讯作者：
Persico,MG