Differential involvement of left temporolateral and temporomesial structures in verbal declarative learning and memory: Evidence from temporal lobe epilepsy
Differential involvement of left temporolateral and temporomesial structures in verbal declarative learning and memory: Evidence from temporal lobe epilepsy
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DOI：
10.1006/brcg.1997.0930
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发表时间：
1997-10-01
影响因子：
2.5
通讯作者：
Elger, CE
中科院分区：
文献类型：
--
作者：
Helmstaedter, C;Grunwald, T;Elger, CE
大量的动物和人类研究已经指出颞叶在记忆处理中的重要作用，但颞叶皮质与内侧结构的不同功能作用仍不清楚。我们研究了语言陈述性记忆，通过使用单词列表范式，区分学习（即时回忆），记忆（延迟回忆）和识别，在癫痫患者被认为是手术切除左颞叶。在术前、事件相关电位（ERP）记录过程中及选择性颅内切除术后评估言语记忆。颞叶皮质病变切除术或前三分之二整块颞叶切除术。作为潜在神经病理学差异的函数的非文字记忆表现的术前差异。并发事件相关电位和术后记忆障碍的特定模式导致了语言陈述性记忆依赖于至少两个功能不同的大脑系统的协同相互作用的证据。材料特定数据采集。或工作记忆，是由新皮层颞叶结构介导的。而长期的巩固/恢复特别是由颞中结构介导的。与左颞叶新皮层相反，颞中系统的功能似乎是非特异性的。显然是的它优先参与言语记忆是由于它与专门用于语言处理的上覆新皮层结构的密切相互作用。(C)1997年学术出版社。
A wealth of animal and human research has pointed to a significant involvement of the temporal lobes in memory processing, and yet the different functional roles of temporal cortical vs. mesial structures remain unclear. We studied verbal declarative memory, by using a word list paradigm that differentiates among learning (immediate recall, memory (delayed recall), and recognition, in epilepsy patients being considered fcr surgical resection of the left temporal lobe. Verbal memory was evaluated preoperatively and during the recording of intracranial event related potentials and postoperatively after selective hippocampectomy. temporal cortical lesionectomy, or anterior two-thirds en bloc temporal lobe resection procedures. Preoperative differences in verbal memory performance as a function of differences in underlying neuropathology. concurrent event-related potentials, and specific patterns of postoperative memory impairments lead to converging evidence that verbal declarative memory relies on a synergistic interaction of at least two functionally distinct brain systems. Material-specific data acquisition. or working memory, is mediated by neocortical temporal structures. whereas long-term consolidation/retrieval is particularly mediated by temporomesial structures. In contrast to the left temporal neocortex, the function of the temporomesial system appears to be material nonspecific. Apparently. its preferential involvement in verbal memory is due to its close interaction with overlying neocortical structures that are specialized for language processing. (C) 1997 Academic Press.