CONNECTIONS OF THE SUBTHALAMIC NUCLEUS WITH VENTRAL STRIATOPALLIDAL PARTS OF THE BASAL GANGLIA IN THE RAT
CONNECTIONS OF THE SUBTHALAMIC NUCLEUS WITH VENTRAL STRIATOPALLIDAL PARTS OF THE BASAL GANGLIA IN THE RAT
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DOI：
10.1002/cne.902940408
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发表时间：
1990-04-22
影响因子：
2.5
通讯作者：
BERENDSE, HW
中科院分区：
文献类型：
--
作者：
GROENEWEGEN, HJ;BERENDSE, HW
本研究旨在建立大鼠丘脑底核(STH)与基底神经节边缘叶传入部分的精确解剖关系。用顺行示踪剂菜豆-亮氨酸凝集素(PHA-L)注射于黑质、苍白球、腹侧苍白球、腹侧纹状体和丘脑束旁核，逆行示踪剂荧光金(FG)和霍乱毒素B(CTB)注射于苍白球腹侧、腹侧纹状体和腹侧中脑。这些追踪实验的结果证实了Sth区和苍白球区域之间相互联系的一般概念。因此，Sth的背内侧部分与连合下的腹侧苍白球相连，而Sth内侧更腹侧的部分与苍白球内侧有关。下丘脑外侧区直接毗邻Sth，含有形态与Sth非常相似的神经元，投射到与嗅结节相关的腹侧苍白球部分。从这个苍白球区域到丘脑底区的相互投射似乎非常稀疏。内侧丘脑束向内侧丘脑内侧核和邻近的下丘脑外侧区发出强投射。从这个内侧纹状体发出的较稀疏的投射到达尾壳核和伏隔核的吻部和内侧部。伏隔核向内侧丘脑发回一个非常稀疏的投射。Sth内侧到腹侧中脑的投射似乎也有一定的地形性组织。下丘脑的外侧和Sth最内侧的一些细胞投射到腹侧被盖区，而腹侧中脑的更多的外侧部分，特别是黑质，依次接受来自Sth的更多的外侧和尾侧部分的输入。此外，许多STH纤维到达中脑锥体外区。丘脑束旁核外侧部投射到背外侧，束旁内侧神经元投射到背内侧。Sth内侧部和相邻的下丘脑外侧与基底节的边缘部分紧密相连，其方式与外侧Sth与基底节的运动相关部分的联系相似和平行。这些发现提示STH在基底节的非运动功能中起作用。
The present study was undertaken to establish the precise anatomical relationship of the subthalamic nucleus (STh) with limbic lobe-afferented parts of the basal ganglia in the rat. The anterograde tracer Phaseolus vulgaris-leucoagglutinin (PHA-L), injected in the STh, the globus pallidus, the ventral pallidum, the ventral striatum, and the parafascicular thalamic nucleus, and the retrograde tracers Fluoro-Gold (FG) and cholera toxin B (CTb), injected in the globus pallidus, the ventral pallidum, the ventral striatium, and the ventral mesencephalon, were used for this purpose. The results of these tracing experiments confirm the general notion of reciprocal connections between the STh and pallidal areas. Thus the dorsomedial part of the STh is connected with the subcommisural ventral pallidum, whereas a more ventral and lateral part of the medial STh is related to the medial globus pallidus. The lateral hypothalamic area, directly adjacent to the STh, containing neurons with a morphology quite similar to those in the STh, projects to parts of the ventral pallidum related to the olfactory tubercle. The reciprocal projection from this pallidal area to subthalamic regions appears to be very sparse. The medial STh sends strong projections to the medial part of the entopeduncular nucleus and the adjacent lateral hypothalamic area. Sparser projections from this medial STh reach the rostral and medial part of the caudate-putamen and the nucleus accumbens. The nucleus accumbens sends a very sparse projection back to the medial STh. The projections of the medial STh to the ventral mesencephalon appear also to be topographically organized. The lateral hypothalamus and a few cells in the most medial part of the STh project to the ventral tegmental area, whereas progressively more lateral parts of the ventral mesencephalon, in particular the substantia nigra, receive input from successively more lateral and caudal parts of the STh. In addition, a number of STh fibers reach the midbrain extrapyramidal area. The lateral part of the parafascicular thalamic nucleus projects to the lateral part of the STh, whereas parafascicular neurons medial to the fasciculus retroflexus project to the dorsomedial portion of the STh. The medial part of the STh and the adjacent lateral hypothalamus are intimately connected with limbic parts of the basal ganglia in a way similar and parallel to the connections of the lateral STh with motor-related parts of the basal ganglia. These findings suggest a role for the STh in nonmotor functions of the basal ganglia.