Routes to regioselective deuteriation of heteroaromatic compounds
Routes to regioselective deuteriation of heteroaromatic compounds
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DOI：
10.1021/ic020226y
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发表时间：
2002-08-12
影响因子：
4.6
通讯作者：
Vos, JG
中科院分区：
文献类型：
--
作者：
Browne, WR;O'Connor, CM;Vos, JG
报道了一种系统的多吡啶型配体的氢化反应方法。使用一系列基于亚临界水介质的方法，以经济有效的方式制备了一系列含有吡嗪、吡啶、1，2，4-三氮唑、噻吩基、甲基和苯基的杂芳烃的同位素。用质谱学、H-1、D-2和C-13核磁共振谱对其进行了表征。讨论了氢化反应在超分子化学中的应用。
A systematic approach to the deuteriation of polypyridyl type ligands is reported. A range of isotopologues of heteroaromatic compounds containing pyrazyl, pyridyl, 1,2,4-triazole, thienyl, methyl, and phenyl moieties, have been prepared in a cost-effective manner, using a range of methods based on subcritical aqueous media. Selectively and fully deuteriated ligands are characterized by mass spectrometry and H-1, D-2, and C-13 NMR spectroscopy. The application of deuteriation to supramolecular chemistry is discussed.