Variation in numbers of CD4+CD25highFOXP3+ T cells with normal immuno-regulatory properties in long-term graft outcome
Variation in numbers of CD4+CD25highFOXP3+ T cells with normal immuno-regulatory properties in long-term graft outcome
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DOI：
10.1111/j.1432-2277.2007.00537.x
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发表时间：
2007-10-01
影响因子：
3.1
通讯作者：
Brouard, Sophie
中科院分区：
文献类型：
--
作者：
Braudeau, Cecile;Racape, Maud;Brouard, Sophie
慢性排斥反应(CR)是移植物长期丢失的主要原因，可通过诱导耐受来避免。我们先前的研究表明，肾移植CR患者的外周血中CD4(+)CD25(High)T细胞数量低于手术耐受患者、移植肾功能稳定的患者和健康志愿者(HV)。在这里，我们探索了这些患者的CD4(+)CD25(高)血液T细胞的特征，重点是它们的调节性T细胞(Treg)基因Forkhead Box P3(FOXP3)的表达及其抑制功能。我们发现CR与调节性正常的CD4(+)CD25(高)FOXP3(+)T细胞数量减少有关，而移植物接受性与类似于HV的CD4(+)CD25(高)FOXP3(+)T细胞数量相关。这些数据表明，Treg数量，而不是其固有的抑制能力，可能有助于决定肾移植的长期命运。
Chronic rejection (CR) is a major cause of long-term graft loss that would be avoided by the induction of tolerance. We previously showed that renal transplant patients with CR have lower numbers of peripheral CD4(+)CD25(high) T cells than operationally tolerant patients, patients with stable graft function and healthy volunteers (HV). We explored here the profile of CD4(+)CD25(high) blood T cells in these patients focusing on their expression of the regulatory T cells (Treg) gene Forkhead Box P3 (FOXP3) and their suppressive function. We show that CR is associated with a decreased number of CD4(+)CD25(high)FOXP3(+)T cells with normal regulatory profile, whereas graft acceptance is associated with CD4(+)CD25(high)FOXP3(+)T cell numbers similar to HVs. These data suggest that Treg numbers, rather than their intrinsic suppressive capacity, may contribute to determining the long-term fate of renal transplants.