Diffusion tensor imaging in multiple sclerosis:: a tool for monitoring changes in normal-appearing white matter
Diffusion tensor imaging in multiple sclerosis:: a tool for monitoring changes in normal-appearing white matter
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DOI：
10.1191/1352458504ms997oa
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发表时间：
2004-01-01
影响因子：
5.8
通讯作者：
Berry, I
中科院分区：
文献类型：
--
作者：
Cassol, E;Ranjeva, JP;Berry, I
我们的目的是确定扩散张量成像（DTI）在志愿者中的可重复性，并评估该方法监测多发性硬化（MS）患者正常外观白色物质（NAWM）纵向变化的能力。对7例MS患者进行了为期一年的DTI检查，其中3例复发缓解型（RRMS），3例继发进展型（SPMS）和1例复发性SP。七个年龄和性别匹配的对照组也进行了为期三个月的每月检查。扩散率和各向异性量化超过分割的整个幕上白色物质，与痕量（Tr）和分数各向异性（FA）的指数。在志愿者中获得的结果显示了该方法的重现性。与对照组相比，患者具有更高的迹线和更低的各向异性（P< 0.0001）。在随访期间，Tr和FA均表明RRMS急性期后恢复，SPMS逐渐向异常值转变。虽然这一结果没有统计学意义，但它表明DTI对常规图像中正常外观的组织中发生的微观变化敏感，并且可以用于监测疾病的过程，即使它无法清楚地区分所涉及的各种生理病理过程。
Our objectives were to determine the reproducibility of diffusion tensor imaging (DTI) in volunteers and to evaluate the ability of the method to monitor longitudinal changes occur ring in the normal-appearing white matter (NAWM) of patients with multiple sclerosis ( MS). DTI was per formed three-monthly for one year in seven MS patients: three relapsing - remitting (RRMS), three secondary progressive (SPMS) and one relapsing SP. They were selected with a limited cerebral lesion load. Seven age- and sex-matched controls also underwent monthly examinations for three months. Diffusivity and anisotropy were quantified over the segmented whole supratentorial white matter, with the indices of trace (Tr) and fractional anisotropy ( FA). Results obtained in volunteers show the reproducibility of the method. Patients had higher trace and lower anisotropy than matched controls (P< 0.0001). Over the follow-up, both Tr and FA indicated a recovery after the acute phase in RRMS and a progressive shift towards abnormal values in SPMS. Although this result is not statistically significant, it suggests that DTI is sensitive to microscopic changes occur ring in tissue of normal appearance in conventional images and could be useful for monitoring the course of the disease, even though it was unable to clearly distinguish between the various physiopathological processes involved.