S-Adenosylmethionine
S-Adenosylmethionine
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DOI：
10.1016/s1357-2725(99)00139-9
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发表时间：
2000-04-01
影响因子：
4
通讯作者：
Lu, SC
中科院分区：
文献类型：
--
作者：
Lu, SC
s -腺苷-硫代蛋氨酸（SAM）是影响正常细胞功能和存活的重要分子。SAM通过三个关键的代谢途径被利用:转甲基化;transsulfuration;还有多胺合成。在转甲基化反应中，SAM的甲基被捐献给多种受体底物，包括DNA、磷脂和蛋白质。因此，这些反应的干扰可以影响从基因表达到膜流动性的广泛过程。在转硫过程中，SAM的硫原子通过一系列酶促步骤转化为半胱氨酸。牛磺酸和谷胱甘肽的前体，主要的细胞抗氧化剂。多胺是正常细胞生长所必需的。考虑到SAM在组织功能中的重要性，这种分子被研究为治疗各种临床疾病的可能治疗剂也就不足为奇了。， (C) 2000爱思唯尔科学有限公司版权所有。
S-Adenosyl-Lmethionine (SAM) is an important molecule in normal cell function and survival. SAM is utilized by three key metabolic pathways: transmethylation; transsulfuration; and polyamine synthesis. In transmethylation reactions, the methyl group of SAM is donated to a large variety of acceptor substrates including DNA, phospholipids and proteins. Thus, interference of these reactions can affect a wide spectrum of processes ranging from gene expression to membrane fluidity. In transsulfuration, the sulfur atom of the SAM is converted via a series of enzymatic steps to cysteine. a precursor of taurine and glutathione, a major cellular antioxidant. Polyamines are required for normal cell growth. Given the importance of SAM in tissue function, it is not surprising that this molecule is being investigated as a possible therapeutic agent for the treatment of various clinical disorders., (C) 2000 Elsevier Science Ltd. All rights reserved.