Long-distance relationships: do membrane nanotubes regulate cell-cell communication and disease progression?
Long-distance relationships: do membrane nanotubes regulate cell-cell communication and disease progression?
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DOI：
10.1091/mbc.e12-08-0622
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发表时间：
2013-04
影响因子：
3.3
通讯作者：
Sherer NM
中科院分区：
文献类型：
--
作者：
Sherer NM
后生动物细胞在紧密的细胞-细胞界面（包括突触和间隙连接）处快速交换信号。成像技术的进步最近揭示了由薄的、含肌动蛋白的膜延伸介导的细胞间串扰的第三种模式，广泛称为“膜”或“隧道”纳米管。大量研究表明纳米管高速公路具有多种功能，包括细胞间电耦合、钙信号传导、小分子交换，以及值得注意的是，大件货物（包括细胞器或病原体）的转移。尽管人们对纳米管及其在细胞信号传导和发病机制中的潜在作用抱有极大的热情，但关于这些结构调节定向细胞间交换的机制仍然存在关键问题。这些连接是如何形成的，在哪些细胞之间形成，最重要的是，纳米管在体内是否像在培养箱中那样普遍存在。
Metazoan cells rapidly exchange signals at tight cell–cell interfaces, including synapses and gap junctions. Advances in imaging recently exposed a third mode of intercellular cross-talk mediated by thin, actin-containing membrane extensions broadly known as “membrane” or “tunneling” nanotubes. An explosion of research suggests diverse functions for nanotubular superhighways, including cell–cell electrical coupling, calcium signaling, small-molecule exchange, and, remarkably, the transfer of bulky cargoes, including organelles or pathogenic agents. Despite great enthusiasm for all things nanotubular and their potential roles in cell signaling and pathogenesis, key questions remain regarding the mechanisms by which these structures regulate directional cell–cell exchange; how these linkages are formed and between which cells and, critically, whether nanotubes are as prevalent in vivo as they appear to be in the incubator.