Tumorigenesis and Neoplastic Progression Multi-Step Aberrant CpG Island Hyper-Methylation Is Associated with the Progression of Adult T–Cell Leukemia/Lymphoma
Tumorigenesis and Neoplastic Progression Multi-Step Aberrant CpG Island Hyper-Methylation Is Associated with the Progression of Adult T–Cell Leukemia/Lymphoma
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CpG岛异常甲基化参与了多种恶性肿瘤的发病机制。然而，很少有人知道成人T细胞白血病/淋巴瘤（ATLL）的表观遗传异常与多步骤致瘤事件的关联。为了确定表观遗传异常是否诱导ATLL的进展，我们通过甲基化特异性PCR分析了65例ATLL患者的SHP 1、p15、p16、p73、HCAD、DAPK、hMLH-1和MGMT基因的甲基化谱。CpG岛甲基化基因的数量随着疾病的进展而增加，甚至在HTLV-1携带者中也检测到特定基因的异常高甲基化，
Aberrant CpG island methylation contributes to the pathogenesis of various malignancies. However, little is known about the association of epigenetic abnormalities with multistep tumorigenic events in adult T cell leukemia/lymphoma (ATLL). To determine whether epigenetic abnormalities induce the progression of ATLL, we analyzed the methylation profiles of the SHP1, p15, p16, p73, HCAD , DAPK, hMLH-1, and MGMT genes by methylation specific PCR assay in 65 cases with ATLL patients. The number of CpG island methylated genes increased with disease progression and aberrant hypermethylation in specific genes was detected even in HTLV-1 carriers and correlated