The International Bacillus anthracis, B. cereus, and B. thuringiensis Conference, "Bacillus-ACT05".
The International Bacillus anthracis, B. cereus, and B. thuringiensis Conference, "Bacillus-ACT05".
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国际炭疽芽孢杆菌、蜡状芽孢杆菌和苏云金芽孢杆菌会议，“芽孢杆菌-ACT05”。
DOI：
10.1128/jb.188.10.3433-3441.2006
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Koehler,TheresaM
中科院分区：
文献类型：
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作者：
Keim,Paul;Mock,Michele;Young,John;Koehler,TheresaM
关于B的新研究成果的证据。在2003年春季于法国尼斯举行的上一次联合会议上，蜡状菌属物种的问题得到了明显的解决，这在一定程度上是由于全球对生物恐怖主义的关注。两年半之后，这些努力取得了成果。在2005年会议的许多会议上，关于宿主-病原体相互作用的新知识显而易见。对炭疽毒素的调查仍然是会议的一个重要组成部分。毒素引起的病理生理变化和先天免疫反应的报告得到了强调和辩论。介绍了以往被致死毒素研究所掩盖的水肿毒素的结构和功能的新信息。此外，来自各种动物感染模型的数据产生了对种属和菌株特异性反应的讨论。虽然许多发言都集中在B。炭疽菌，相当多的时间也花在其他物种的B。cereus组，并揭示了重要的相似性和差异的物种。这些物种的生态学是一个长期被忽视的研究领域，在会议上引起了人们的注意，其中包括关于土壤和昆虫肠道中细菌生活方式的报告。B。炭疽菌基因组学的大爆发对所有这三个物种的研究都产生了重大影响。基因组学不仅允许描绘由B组成的系统发育树。cereus组菌株，但促进了关于组内特定生理差异的新假设的产生。为B开发的创新分子流行病学工具。炭疽菌将广泛应用于其他细菌种类的分析。最后，人们对孢子结构产生了相当大的兴趣。外孢壁是B孢子表面的一层特殊的外膜。cereus集团，进行了询问和审议。代表20多个国家的约350名与会者聚集一堂，讨论了213项口头和海报介绍。本会议报告主要限于口头发言的要点。
Evidence of new research efforts concerning the B. cereus group species, fueled in part by global concerns related to bioterrorism, was apparent at the previous joint meeting held in the spring of 2003 in Nice, France. Two and one-half years later, fruits of these efforts were realized. New knowledge of host-pathogen interactions was apparent in many sessions of the 2005 conference. Investigations of the anthrax toxin remained a vital component of the meeting. Reports of toxininduced physiopathological changes and the innate immune response were emphasized and debated. New information regarding the structure and function of edema toxin, previously overshadowed by studies of lethal toxin, was presented. In addition, data from various animal models of infection generated discussions of species-and strain-specific responses. While numerous presentations focused on B. anthracis, considerable time was also spent on other species of the B. cereus group, and important similarities and differences in the species were revealed. The ecology of these species, a long-neglected area of investigation, gained attention at the meeting, which included reports concerning lifestyles of the bacteria in the soil and in the insect gut. The B. anthracis genomics explosion has had a major impact on research in all three species. Genomics not only has permitted delineation of phylogenetic trees comprised of B. cereus group strains, but has fostered generation of new hypotheses regarding specific physiological differences within the group. The innovative molecular epidemiology tools developed for B. anthracis will have broad application for analysis of other bacterial species. Finally, considerable interest in spore structure has emerged. The composition and function of the exosporium, an outer coating specific to the surface of spores of the B. cereus group, were queried and deliberated. Approximately 350 participants representing over 20 countries gathered to discuss 213 oral and poster presentations. This meeting report is limited primarily to highlights of oral presentations.