Omega-3 Fatty Acids and Skeletal Muscle Health.
Omega-3 Fatty Acids and Skeletal Muscle Health.
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omega-3脂肪酸和骨骼肌健康。
DOI：
10.3390/md13116977
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发表时间：
2015-11-19
期刊：
影响因子：
5.4
通讯作者：
Hamilton DL
中科院分区：
文献类型：
--
作者：
Jeromson S;Gallagher IJ;Galloway SD;Hamilton DL
骨骼肌是一种塑料组织，能够适应和不适应身体活动和饮食。骨骼肌对适应性刺激（例如运动）的反应可以通过肌肉先前的营养状况来改变。营养对骨骼肌的影响有可能对身体功能和全身代谢产生重大影响。基于动物和细胞的模型表明，omega-3 脂肪酸，尤其是海洋来源的脂肪酸，可以影响骨骼肌代谢。此外，最近的人类研究表明，海洋来源的 omega-3 脂肪酸可以影响骨骼肌的运动和营养反应。这些研究表明，之前的 omega-3 状态不仅影响肌肉对营养的代谢反应，还影响一段时间运动训练的功能反应。因此，海洋来源的 Omega-3 脂肪酸有可能改变许多人类疾病的轨迹，包括与衰老相关的身体衰退。我们探索 omega-3 脂肪酸在骨骼肌中发挥作用的潜在分子机制，考虑 n-3/n-6 比率、炎症和脂质组学重塑作为可能的作用机制。最后，我们提出了一些进一步研究的途径，以阐明 omega-3 脂肪酸如何在骨骼肌中发挥其生物作用。
Skeletal muscle is a plastic tissue capable of adapting and mal-adapting to physical activity and diet. The response of skeletal muscle to adaptive stimuli, such as exercise, can be modified by the prior nutritional status of the muscle. The influence of nutrition on skeletal muscle has the potential to substantially impact physical function and whole body metabolism. Animal and cell based models show that omega-3 fatty acids, in particular those of marine origin, can influence skeletal muscle metabolism. Furthermore, recent human studies demonstrate that omega-3 fatty acids of marine origin can influence the exercise and nutritional response of skeletal muscle. These studies show that the prior omega-3 status influences not only the metabolic response of muscle to nutrition, but also the functional response to a period of exercise training. Omega-3 fatty acids of marine origin therefore have the potential to alter the trajectory of a number of human diseases including the physical decline associated with aging. We explore the potential molecular mechanisms by which omega-3 fatty acids may act in skeletal muscle, considering the n-3/n-6 ratio, inflammation and lipidomic remodelling as possible mechanisms of action. Finally, we suggest some avenues for further research to clarify how omega-3 fatty acids may be exerting their biological action in skeletal muscle.