Adaptive evolution of an sRNA that controls Myxococcus development.
Adaptive evolution of an sRNA that controls Myxococcus development.
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DOI：
10.1126/science.1187200
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发表时间：
2010-05-21
期刊：
影响因子：
--
通讯作者：
Velicer GJ
中科院分区：
文献类型：
--
作者：
Yu YT;Yuan X;Velicer GJ
小RNA （sRNA）分子在生物学中调控着大量的过程，但是关于sRNA序列适应性进化的证据一直是间接的。在这里，我们发现了一个sRNA， Pxr，负向调节黄粘球菌的子实体发育。我们进一步表明，Pxr的自发进化突变取消了其调节功能，从而适应性地恢复了对社会缺陷的发育能力。xanthuscheater。在wild-typeM。黄原石的发育仅在饥饿时开始，但删除黄原石可以在营养充足的情况下继续发育。因此，Pxr在黏菌中是控制从生长到发育过渡的主要检查点。这些发现表明，sRNA分子控制着原核生物多细胞发育的复杂形式，并直接证明了sRNA调节因子促进主要表型效应的进化适应的能力。
Small RNA (sRNA) molecules regulate a vast array of processes in biology, but evidence for adaptive evolution of sRNA sequences has been indirect. Here, we identify an sRNA, Pxr, that negatively regulates fruiting body development inMyxococcus xanthus.We further show that a spontaneous evolutionary mutation in Pxr abolished its regulatory function and thereby adaptively restored developmental proficiency to a socially defectiveM. xanthuscheater. In wild-typeM. xanthus, development is initiated only upon starvation, but deletion ofpxrallows development to proceed even while nutrients remain abundant. Thus, Pxr serves as a major checkpoint controlling the transition from growth to development in the myxobacteria. These findings show that an sRNA molecule governs a complex form of multicellular development in prokaryotes and directly demonstrate the ability of sRNA regulators to facilitate evolutionary adaptations of major phenotypic effect.
影响因子：
10.5
作者：
Harris, BZ;Kaiser, D;Singer, M
通讯作者：
Singer, M
影响因子：
64.8
作者：
Fiegna, F;Yu, YTN;Velicer, GJ
通讯作者：
Velicer, GJ