THE ASSOCIATION OF APOLIPOPROTEIN-E POLYMORPHISM WITH MEMORY - A POPULATION-BASED STUDY
THE ASSOCIATION OF APOLIPOPROTEIN-E POLYMORPHISM WITH MEMORY - A POPULATION-BASED STUDY
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DOI：
10.1016/0304-3940(95)11575-h
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发表时间：
1995-05-26
影响因子：
2.5
通讯作者：
RIEKKINEN, P
中科院分区：
文献类型：
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作者：
HELKALA, EL;KOIVISTO, K;RIEKKINEN, P
一些研究表明载脂蛋白epsilon 4等位基因与阿尔茨海默病（AD）之间存在关联，等位基因epsilon 2与生存和寿命有关。我们希望在916名非痴呆老年受试者的随机样本中检验认知效率与载脂蛋白E多态性（APOE）之间是否存在关系。情景记忆是通过列表学习测试，以及即时和延迟回忆这些数字来检验的。语义记忆采用类别测试和语言流畅性测试。通过抄写图形来考察建构能力。注意功能采用Trail Making A和B测试。我们发现APOE E2/2和2/3表型的受试者比APOE E2/4、3/4和4/4表型的受试者表现出更好的学习能力。APOE e2 / 4,3 / 4,4 /4表型受试者的记忆受损与心血管疾病的过度无关。因此，它们可能至少部分地与遗传因素有关。
Several studies have shown an association between the apolipoprotein epsilon 4 allele and Alzheimer's disease (AD), The allele epsilon 2 has been associated with survival and longevity. We wanted to examine whether the relationship between cognitive efficiency and apolipoprotein E polymorphism (APOE) exists in a random sample of 916 non-demented elderly subjects. Episodic memory was examined with the list learning test, and with immediate and delayed recall of the figures. Semantic memory was examined with the Category and Verbal Fluency Tests. Constructional abilities were examined by copying the figures. Attention functions were examined with Trail Making A and B tests. We found that subjects with APOE E2/2 and 2/3 phenotypes showed better learning ability than those subjects with the APOE E2/4, 3/4 or 4/4 phenotypes. Impaired memory was not related to the excess of cardiovascular diseases in the subjects with APOE E2/4, 3/4, 4/4 phenotypes. Thus they may be associated, at least partly, with genetic factors.