MicroRNAs in control of gene regulatory programs in diabetic vasculopathy.
MicroRNAs in control of gene regulatory programs in diabetic vasculopathy.
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DOI：
10.2741/4494
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Chongzhe Pei;Xiaoping Zhang;S. Meng;Yigang Li
中科院分区：
文献类型：
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作者：
Chongzhe Pei;Xiaoping Zhang;S. Meng;Yigang Li
糖尿病通常与血管病变相关，其包含微血管和大血管并发症，与高发病率和死亡率相关。目前，尽管有介入治疗，糖尿病血管病变患者的总体预后仍不令人满意。血管生成和血管损伤与修复与多种细胞有关。然而，参与糖尿病血管病变发病机制的细胞的分子机制仍然在很大程度上未知。microRNAs（miRs）作为一种新型分子，参与了转录后水平蛋白质编码基因表达的调控，参与了多种慢性代谢性疾病，尤其是糖尿病血管病变的发病机制。这使得miR在调节各种细胞事件中具有直接功能。此外，循环miR已被提议作为广泛的心血管疾病的生物标志物。本文综述了miR介导的糖尿病血管病变的调控机制。此外，我们还讨论了目前对糖尿病血管病变中miR的认识。最后，我们总结了与miR相关的糖尿病血管病变的新诊断和治疗策略的发展。
Diabetes is generally associated with vasculopathy, which contains both microvascular and macrovascular complications, associated with high morbidity and mortality. Currently, despite interventional therapy, the overall prognosis for patients with diabetic vasculopathy remains unsatisfactory. Angiogenesis and vascular injury and repair are associated with a variety of cells. However, the molecular mechanisms of the cells that are involved in pathogenesis of diabetic vasculopathy remain largely unknown. As novel molecules, microRNAs (miRs) take part in regulating protein-coding gene expression at the post-transcriptional level, and contribute to the pathogenesis of various types of chronic metabolism disease, especially diabetic vasculopathy. This allows miRs to have a direct function in regulation of various cellular events. Additionally, circulating miRs have been proposed as biomarkers for a wide range of cardiovascular diseases. This review elucidates miR-mediated regulatory mechanisms in diabetic vasculopathy. Furthermore, we discuss the current understanding of miRs in diabetic vasculopathy. Finally, we summarize the development of novel diagnostic and therapeutic strategies for diabetic vasculopathy related to miRs.