Endothelial cell activation in men with erectile dysfunction without cardiovascular risk factors and overt vascular damage
Endothelial cell activation in men with erectile dysfunction without cardiovascular risk factors and overt vascular damage
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DOI：
10.1097/01.ju.0000116325.06572.85
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发表时间：
2004-04-01
影响因子：
6.6
通讯作者：
Francavilla, S
中科院分区：
文献类型：
--
作者：
Bocchio, M;Desideri, G;Francavilla, S
目的：内皮细胞活化（ECA）是动脉粥样硬化的起始事件。在与心血管危险因素（VRF）相关或不相关的勃起功能障碍（艾德）患者中评估ECA的生化测量，以评估艾德是否是动脉粥样硬化的哨兵。对45名患有艾德但无VRF的男性进行了循环可溶性P-选择素、细胞间粘附分子-1、血管细胞粘附分子-1和内皮素-1浓度的评估，45例艾德伴VRF患者和25例健康男性。结果：艾德组ECA明显高于对照组（P < 0.05），而无VRF组ECA明显高于对照组（P < 0.05），但无VRF组ECA明显高于对照组（P < 0.05）。
Purpose: Endothelial cell activation (ECA) is an initiating event in atherosclerosis. Biochemical measures of ECA were evaluated in patients with erectile dysfunction (ED) associated or not associated with cardiovascular risk factors (VRFs) to assess whether ED is a sentinel of atherosclerosis.Materials and Methods: Circulating soluble P-selectin, intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and endothelin-1 concentrations were assessed in 45 men with ED but no VRFs, 45 men with ED associated with VRFs and 25 healthy men. Ultrasound intima-media thickness of carotid arteries and pharmacologically stimulated peak systolic velocity of cavernous arteries were used to assess vascular damage.Results: Measures of ECA were higher in men with ED but no VRFs than in controls (p