Arterial stiffness and sedentary lifestyle: Role of oxidative stress
Arterial stiffness and sedentary lifestyle: Role of oxidative stress
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DOI：
10.1016/j.vph.2015.05.017
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发表时间：
2016-04-01
影响因子：
4
通讯作者：
Davi, Giovanni
中科院分区：
文献类型：
--
作者：
Lessiani, Gianfranco;Santilli, Francesca;Davi, Giovanni
久坐不动的生活方式是心血管疾病发展的危险因素，并导致血管功能和动脉壁硬化的可量化损害。我们测试了氧化应激作为身体活动不活跃的受试者动脉僵硬度（AS）的决定因素的假设，并在完成8周高强度运动训练（Er）后挑战这些过程的可逆性。AS在ET前后进行评估，用Vicorder设备测量颈动脉至股动脉脉搏波速度（PWV）。在基线和ET后，参与者进行尿液收集和空腹采血。测定尿8-iso-PGF（2 α）（体内脂质过氧化的标志物）、总胆固醇、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇以及甘油三酯浓度。PWV在ET完成后显著降低（p < 0.0001），并且与尿8-iso-PGF（2 α）直接相关（Rho = 0.383，p = 0.021）。ET后，心血管适应性改善[峰值耗氧量（p < 0.0001），峰值心率（p < 0.0001）]。然而，除了甘油三酯显著降低（p = 0.022）外，未观察到血脂谱改善。在整个研究期间，PWV和甘油三酯显著相关（Rho = 0.466，p = 0.005）。在我们以前久坐的受试者中，PWV水平也与尿8-iso-PGF（2 α）相关。我们的结论是，定期体育锻炼可能是一种天然的抗氧化剂策略，降低氧化应激，从而AS程度。(C)2015爱思唯尔公司All rights reserved.
Sedentary lifestyle is a risk factor for the development of cardiovascular disease, and leads to a quantifiable impairment in vascular function and arterial wall stiffening. We tested the hypothesis of oxidative stress as a determinant of arterial stiffness (AS) in physically inactive subjects, and challenged the reversibility of these processes after the completion of an eight-week, high-intensity exercise training (Er).AS was assessed before and after ET, measuring carotid to femoral pulse wave velocity (PWV) with a Vicorder device. At baseline and after ET, participants performed urine collection and underwent fasting blood sampling. Urinary 8-iso-PGF(2 alpha), an in vivo marker of lipid peroxidation, total, HDL and LDL cholesterol, and triglyceride concentrations were measured.ET was associated with significantly reduced urinary 8-iso-PGF(2 alpha)(p < 0.0001) levels. PWV was significantly reduced after ET completion (p < 0.0001), and was directly related to urinary 8-iso-PGF(2 alpha)(Rho = 0.383, p = 0.021). After ET, cardiovascular fitness improved [peak oxygen consumption (p < 0.0001), peak heart rate (p < 0.0001)]. However, no improvement in lipid profile was observed, apart from a significant reduction of triglycerides (p = 0.022). PWV and triglycerides were significantly related (Rho = 0.466, p = 0.005) throughout the study period. PWV levels were also related to urinary 8-iso-PGF(2 alpha) in our previously sedentary subjects. We conclude that regular physical exercise may be a natural antioxidant strategy, lowering oxidant stress and thereby the AS degree. (C) 2015 Elsevier Inc. All rights reserved.