Focal nodular hyperplasia-like lesion of the liver with focal adenoma features associated with idiopathic portal hypertension
Focal nodular hyperplasia-like lesion of the liver with focal adenoma features associated with idiopathic portal hypertension
复制标题
肝脏局灶性结节性增生样病变，伴有局灶性腺瘤特征，与特发性门静脉高压相关
DOI：
10.1111/hepr.12273
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发表时间：
2014
期刊：
影响因子：
4.2
通讯作者：
Moriyasu F
中科院分区：
文献类型：
--
作者：
Sugimoto K;Kondo F;Furuichi Y;Oshiro H;Nagao T;Saito K;Yoshida H;Imai Y;Fukusato T;Moriyasu F
近年来，由于分子标准的应用，局灶性结节增生(FNH)和肝细胞腺瘤(HCA)的诊断取得了很大进展。这使我们能够识别一种新类型的肝脏结节。在此病例中，我们报告一位男性患者，其肝脏结节合并特发性门脉高压症(IPH)，病理上不仅表现出FNH的形态特征，如导管反应、扩张的血窦、主要血管异常和免疫组织化学“地图样”的谷氨酰胺合成酶(GS)模式，而且还表现出局灶性HCA的免疫组织学特征，如血清淀粉样蛋白A和C反应蛋白的强表达和GS的弱表达。最终诊断为FNH样病变伴局灶性炎性肝细胞腺瘤。
Great progress has been made in the diagnosis of focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) in the last few years due to the use of molecular criteria. This has allowed us to identify a new type of hepatic nodule. In this case report, we present a male patient with a hepatic nodule associated with idiopathic portal hypertension (IPH) pathologically exhibiting not only the morphological features of FNH, such as ductular reactions, dilated sinusoids, major vascular abnormalities and an immunohistochemical “map‐like” pattern of glutamine synthetase (GS), but also the immunohistological features of focal HCA, such as strong expression of serum amyloid A and C‐reactive protein and weak expression of GS. As the final diagnosis, the nodule was identified as an FNH‐like lesion with focal inflammatory hepatocellular adenoma.