Expression of activin receptor-like kinase 7 in adipose tissues.
Expression of activin receptor-like kinase 7 in adipose tissues.
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脂肪组织中激活素受体样激酶 7 的表达。
DOI：
10.1007/s10528-012-9555-8
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
Murakami M. et al.
中科院分区：
文献类型：
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作者：
Kumiko Asai;Masayuki Funaba and Masaru Murakami;Murakami M. et al.
检测了激活素受体样激酶7（Alk 7）表达的组织分布、Alk 7变体的信号传导能力以及Alk 7对β3-肾上腺素能受体激活的响应表达。Alk 7的表达水平在不同组织中差异很大，但在白色脂肪组织和棕色脂肪组织中最高。除了全长Alk 7（Alk 7-v1）之外，Alk 7-v3（Alk 7变体）在脂肪组织、脑和卵巢中表达。Nodal通过Alk 7与其辅助受体Cripto合作传输信号。使用基于内切酶的报告基因测定对Alk 7变体赋予Nodal信号传导的能力的评估显示，Alk 7-v3不传递Nodal-Cripto介导的信号。用β3-肾上腺素能受体激动剂CL 316，243处理的棕色脂肪组织中Alk 7的表达下调，但在白色脂肪组织中没有下调。这些结果表明Alk 7参与调节响应于β3-肾上腺素能受体活化的脂肪组织中的代谢。
The tissue distribution of activin receptor-like kinase 7 (Alk7) expression, the signaling ability of Alk7 variants, and Alk7 expression in response to β3-adrenergic receptor activation were examined. Expression levels ofAlk7varied greatly among tissues but were highest in white adipose tissue and brown adipose tissue. In addition to full-length Alk7 (Alk7-v1),Alk7-v3, an Alk7 variant, was expressed in adipose tissues, brain, and ovary. Nodal transmits signals via Alk7 in cooperation with its coreceptor, Cripto. Evaluation of the ability of Alk7 variants to confer Nodal signaling using luciferase-based reporter assays showed that Alk7-v3 does not transmit Nodal-Cripto-mediated signals. Expression ofAlk7was down-regulated in brown but not in white adipose tissue treated with CL316,243, a β3-adrenergic receptor agonist. These results suggest involvement of Alk7 in modulation of metabolism in the adipose tissues in response to β3-adrenergic receptor activation.