Ectopic Laryngeal Ossification after Bone Morphogenetic Protein-2.
Ectopic Laryngeal Ossification after Bone Morphogenetic Protein-2.
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DOI：
10.3390/surgeries2040038
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Long J
中科院分区：
文献类型：
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作者：
Wong K;Damrose E;Long J
我们报告两例异位骨形成的头部和颈部治疗后，重组人骨形态发生蛋白-2（rhBMP-2）。获得手术病理资料、喉镜成像、CT成像和患者病史。首先，我们报告了一名67岁男性在下颌骨种植体植入rhBMP-2后声带骨化生;其次，一名73岁男性在多次颈椎前路椎间盘切除术和rhBMP-2融合术后出现喉部严重骨过度生长并融合到颈椎前路（ACS）。rhBMP-2后异位骨形成先前已有报道。颈椎应用rhBMP-2后，局部肿胀和水肿导致吞咽困难甚至气道阻塞等不良事件也有广泛报道。由于头部和颈部软组织区域异常骨生长的不常见性以及先前记录的rhBMP-2使用的不良反应，特别是在颈椎中，我们认为两种异位骨形成的不寻常病例表现极有可能与rhBMP-2相关。我们敦促认识rhBMP-2引起的不良反应，并敦促谨慎给药。
We report two cases of ectopic bone formation in the head and neck following treatment with recombinant human bone morphogenetic protein-2 (rhBMP-2). Surgical pathologic data, laryngoscopy imaging, CT imaging, and patient medical history were obtained. First, we report osseous metaplasia in the vocal fold in a 67-year-old male following mandibular dental implants with rhBMP-2; second, a case of severe bony overgrowth of the larynx and fusion to the anterior cervical spine (ACS) in a 73-year-old male following multiple anterior cervical discectomies and fusions with rhBMP-2. Ectopic bone formation following rhBMP-2 has been previously reported. Adverse events like local swelling and edema leading to dysphagia and even airway obstruction after cervical spine application of rhBMP-2 have also been widely reported. Due to the uncommon nature of abnormal bony growth in soft tissue areas of the head and neck and the previously documented adverse effects of rhBMP-2 use, especially in the cervical spine, we consider the two unusual case presentations of ectopic bony formation highly likely to be linked with rhBMP-2. We urge awareness of the adverse effects caused by rhBMP-2, and urge caution in dosing.