Spatiotemporal Dynamics of Functional Clusters of Neurons in the Mouse Motor Cortex during a Voluntary Movement
Spatiotemporal Dynamics of Functional Clusters of Neurons in the Mouse Motor Cortex during a Voluntary Movement
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DOI：
10.1523/jneurosci.2550-12.2013
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发表时间：
2013-01-23
影响因子：
5.3
通讯作者：
Matsuzaki, Masanori
中科院分区：
文献类型：
--
作者：
Hira, Riichiro;Ohkubo, Fuki;Matsuzaki, Masanori
在运动皮层中经常观察到神经元的功能聚集。然而，这是未知的，如果，何时，以及如何精细规模（3秒拉一次。我们在小鼠体内发现了两种与任务相关的细胞：在杠杆拉动过程中出现峰值活动的细胞（拉动细胞）和在杠杆拉动结束后出现峰值活动的细胞。牵拉细胞的活性与牵拉持续时间密切相关。在类似的40%的成像领域，功能聚类检测时间在杠杆拉动。在空间上，有类似的70亩米规模的集群，由四个以上的拉细胞在类似的50%的领域。集群内的拉细胞的包围和个体活动比集群外的拉细胞的活动更准确地预测杠杆运动轨迹。这可能是因为成簇的拉细胞在单独的试验中比簇外的拉细胞更活跃。这种更高的保真度的活动有关的较高的试验到试验的相关性的活动对集群内。我们建议，强大的经常性网络集群可能代表自愿运动的执行。
Functional clustering of neurons is frequently observed in the motor cortex. However, it is unknown if, when, and how fine-scale (3 s to pull it again. We found two types of task-related cells in the mice: cells whose peak activities occurred during lever pulls (pull cells) and cells whose peak activities occurred after the end of lever pulls. The activity of pull cells was strongly associated with lever-pull duration. In similar to 40% of imaged fields, functional clusterings were temporally detected during the lever pulls. Spatially, there were similar to 70-mu m-scale clusters that consisted of more than four pull cells in similar to 50% of the fields. Ensemble and individual activities of pull cells within the cluster more accurately predicted lever movement trajectories than activities of pull cells outside the cluster. This was likely because clustered pull cells were more often active in the individual trials than pull cells outside the cluster. This higher fidelity of activity was related to higher trial-to-trial correlations of activities of pairs within the cluster. We propose that strong recurrent network clusters may represent the execution of voluntary movements.