Serotonin regulation of aggressive behavior in male golden hamsters (Mesocricetus auratus).
Serotonin regulation of aggressive behavior in male golden hamsters (Mesocricetus auratus).
复制标题
血清素对雄性金仓鼠（Mesocricetus auratus）攻击行为的调节。
DOI：
10.1037//0735-7044.113.4.804
复制
发表时间：
1999
影响因子：
1.9
通讯作者：
Delville,Y
中科院分区：
文献类型：
--
作者：
Ferris,CF;Stolberg,T;Delville,Y
These studies examined the neurochemistry and neuroanatomy of the serotonin (5-HT) system innervating the anterior hypothalamus (AH) and the interaction of 5-HT receptor agonists with arginine vasopressin (AVP) in the regulation of offensive aggression in golden hamsters. Because specific 5-HT 1A, 5-HT 1B, and AVP V 1A binding sites were observed within the AH by in vitro autoradiography, the hamsters were tested for offensive aggression after microinjections of AVP in combination with either the 5-HT 1A agonist 8-hydroxy-2-(di-n-propylamino) tetraline (DPAT) or the 5-HT 1B agonist CGS-12066A (CGS) directly within the AH. Though treatment with DPAT resulted in a dose-dependent inhibition of AVP-facilitated offensive aggression, CGS was ineffective. In addition, a retrograde tracer was injected within the AH to localize the distribution of 5-HT neurons projecting to the area. Retrogradely labeled 5-HT neurons were found within the dorsal, median, and caudal linear raphe nuclei and are suspected to inhibit AVP-facilitated offensive aggression by an activation of 5-HT 1A receptors in the AH.
