Epigenetic regulation of chronic pain.
Epigenetic regulation of chronic pain.
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作者：
Liang L;Lutz BM;Bekker A;Tao YX
由外周炎症和组织或神经损伤引起的慢性疼痛是常见的临床症状。虽然在过去的几十年中，人们对慢性疼痛的神经生物学机制进行了深入的研究，但目前的药物如阿片类药物和非甾体抗炎药对这种疾病的管理仍然很差。炎症、组织损伤和/或神经损伤诱导的背根神经节（DRG）、脊髓背角和疼痛相关脑区感觉神经元基因表达的变化被认为参与慢性疼痛的发生;然而，这些变化如何发生仍然是难以捉摸的。表观遗传修饰包括DNA甲基化和共价组蛋白修饰控制基因表达。最近的研究表明，外周伤害性刺激改变DNA甲基化和组蛋白修饰，这些变化可能与慢性疼痛条件下疼痛超敏反应的诱导有关。本文综述了慢性疼痛表观遗传学研究的现状和进展，并讨论了表观遗传修饰作为治疗性抗伤害性靶点在慢性疼痛中的潜在作用。
Chronic pain arising from peripheral inflammation and tissue or nerve injury is a common clinical symptom. Although intensive research on the neurobiological mechanisms of chronic pain has been carried out during previous decades, this disorder is still poorly managed by current drugs such as opioids and non-steroidal anti-inflammatory drugs. Inflammation-, tissue injury-, and/or nerve injury-induced changes in gene expression in sensory neurons of the dorsal root ganglion (DRG), spinal cord dorsal horn, and pain-associated brain regions are thought to participate in chronic pain genesis; however, how these changes occur is still elusive. Epigenetic modifications including DNA methylation and covalent histone modifications control gene expression. Recent studies have shown that peripheral noxious stimulation changes DNA methylation and histone modifications and that these changes may be related to the induction of pain hypersensitivity under chronic pain conditions. This review summarizes the current knowledge and progress in epigenetic research in chronic pain and discusses the potential role of epigenetic modifications as therapeutic antinociceptive targets in this disorder.
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影响因子：
2
作者：
Downs, Jenny;Geranton, Sandrine M.;Bebbington, Ami;Jacoby, Peter;Bahi-Buisson, Nadia;Ravine, David;Leonard, Helen
通讯作者：
Leonard, Helen
Dnmt1 和 Dnmt3a 维持 DNA 甲基化并调节成人前脑神经元的突触功能
影响因子：
25
作者：
Feng, Jian;Zhou, Yu;Campbell, Susan L.;Le, Thuc;Li, En;Sweatt, J. David;Silva, Alcino J.;Fan, Guoping
通讯作者：
Fan, Guoping
影响因子：
4
作者：
Cuddapah VA;Pillai RB;Shekar KV;Lane JB;Motil KJ;Skinner SA;Tarquinio DC;Glaze DG;McGwin G;Kaufmann WE;Percy AK;Neul JL;Olsen ML
通讯作者：
Olsen ML
DOI：
10.1046/j.1432-1033.2002.03198.x
发表时间：
2002-10-01
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
Fatemi, M;Hermann, A;Jeltsch, A
通讯作者：
Jeltsch, A
影响因子：
2.5
作者：
He, Xin;Ou, Peng;Guo, Qulian
通讯作者：
Guo, Qulian