Probability of identical monomorphism in related species.
Probability of identical monomorphism in related species.
复制标题
相关物种中相同单态性的概率。
DOI：
10.1017/s0016672300015822
复制
发表时间：
1975
期刊：
影响因子：
--
通讯作者：
W.
中科院分区：
文献类型：
--
作者：
M. Nei;W.
在中性突变假设下，提出了一种估算同一等位基因在近缘物种中为单态的概率的数学方法。文中还给出了相同单态基因座在近缘物种中所占比例的公式。将这种方法应用于果蝇数据的结果并不支持Prakash&Lewontin(1968)的观点，即基因排列(倒置染色体)与蛋白质座位上的等位基因之间的强烈关联是倒置染色体片段基因共适应的证据。同样，与Haigh&Maynard Smith(1972)的论点不同，人类中血红蛋白a链基因的单态可以用中性突变假说来适应，而不会引发瓶颈效应。
A mathematical method for evaluating the probability that a locus is monomorphic for the same allele in related species is developed under the neutral mutation hypothesis. A formula for the proportion of identically monomorphic loci in related species is also worked out. The results of the application of this method to Drosophila data do not support Prakash & Lewontin's (1968) contention that the strong association between gene arrangements (inversion chromosomes) and alleles at protein loci is evidence of coadaptation of genes in the inverted segment of chromosomes. Similarly, unlike Haigh & Maynard Smith's (1972) contention, the monomorphism of the haemoglobin a chain locus in man can be accommodated with the neutral mutation hypothesis without invoking the bottleneck effect.