The cost of inbreeding in Arabidopsis
The cost of inbreeding in Arabidopsis
复制标题
DOI：
10.1038/416531a
复制
发表时间：
2002-04-04
期刊：
影响因子：
64.8
通讯作者：
Hartl, DL
中科院分区：
文献类型：
--
作者：
Bustamante, CD;Nielsen, R;Hartl, DL
群体遗传学家长期以来一直试图估计基因组中不同功能基因之间的选择强度分布。直到最近，DNA测序和分析技术的融合才使这成为可能。重要的进展来自于比较物种内的遗传变异（多态性）与物种间的固定差异（分歧）（1，2）。这些方法已被用来检查单个基因的选择的证据。在这里，我们使用的事实是，自物种分化以来的时间允许跨基因的数据组合。在比较氨基酸替换物种之间的芥菜杂草拟南芥与果蝇的物种之间，我们发现的证据，主要是有益的基因取代果蝇，但主要是有害的取代拟南芥。我们将这种差异归因于部分自花受精的拟南芥交配系统，这证实了群体遗传学理论的预测（3-6），即具有高频率近亲繁殖的物种由于其有效群体大小的减少而在消除有害突变方面效率较低。
Population geneticists have long sought to estimate the distribution of selection intensities among genes of diverse function across the genome. Only recently have DNA sequencing and analytical techniques converged to make this possible. Important advances have come from comparing genetic variation within species (polymorphism) with fixed differences between species (divergence)(1,2). These approaches have been used to examine individual genes for evidence of selection. Here we use the fact that the time since species divergence allows combination of data across genes. In a comparison of amino-acid replacements among species of the mustard weed Arabidopsis with those among species of the fruitfly Drosophila, we find evidence for predominantly beneficial gene substitutions in Drosophila but predominantly detrimental substitutions in Arabidopsis. We attribute this difference to the Arabidopsis mating system of partial self-fertilization, which corroborates a prediction of population genetics theory(3-6) that species with a high frequency of inbreeding are less efficient in eliminating deleterious mutations owing to their reduced effective population size.