Binding of [3H]ADTN to rat striatal membranes.
Binding of [3H]ADTN to rat striatal membranes.
复制标题
[3H]ADTN 与大鼠纹状体膜的结合。
DOI：
10.1016/0006-2952(82)90391-4
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发表时间：
1982
影响因子：
5.8
通讯作者：
G. Woodruff
中科院分区：
文献类型：
--
作者：
W. W. Templeton;G. Woodruff
构象受限的多巴胺类似物ADTN以一种特定的饱和方式与大鼠纹状体膜结合。对数据的分析表明只有一个结合位点。[~3H]ADTN的结合被广泛的多巴胺激动剂和拮抗剂(包括典型和非典型的)所取代。ADTN衍生物取代[~3H]ADTN的效力与它们在其他体内和体外试验中作为激动剂的活性很好地相关。
The conformationally restricted dopamine analogue ADTN binds in a specific saturable manner to rat striatal membranes. Analysis of the data suggests a single binding site. Binding of [3H]ADTN is displaced by a wide range of dopamine agonists and antagonists (both typical and atypical). The potency of ADTN derivatives to displace [3H]ADTN correlates well with their activity as agonists in other tests bothin vivoandin vitro.