Pepluane and Paraliane Diterpenoids from Euphorbia peplus with Potential Anti-inflammatory Activity
Pepluane and Paraliane Diterpenoids from Euphorbia peplus with Potential Anti-inflammatory Activity
复制标题
大戟中的 Pepluane 和 Paraliane 二萜类化合物具有潜在的抗炎活性
DOI：
10.1021/acs.jnatprod.6b00206
复制
发表时间：
2016
影响因子：
5.1
通讯作者：
Qiu Ming-Hua
中科院分区：
文献类型：
--
作者：
Wan Luo-Sheng;Chu Rui;Peng Xing-Rong;Zhu Guo-Lei;Yu Mu-Yuan;Li Lei;Zhou Lin;Lu Shuang-Yang;Dong Jin-Run;Zhang Zhi-Run;Li Yan;Qiu Ming-Hua
从胡杨的丙酮提取物中分离出了12个新的二萜类化合物，这些化合物基于两种罕见的骨架类型，即副烷酮A-D（1-4）和对烷醇A-H(5-12)，以及5个已知的化合物。基于一维和二维核磁共振数据分析，提出了它们的结构。这些二萜在脂多糖刺激的小鼠巨噬细胞模型中评估了潜在的抗炎活性。化合物3、4、11、13、16对NO具有中等抑制作用，ic50值在29.9 ~ 38.3 μM之间。
Twelve new diterpenoids based on two rare skeletal types, namely, paralianones A–D (1–4) and pepluanols A–H (5–12), along with five known compounds, were isolated from an acetone extract ofEuphorbia peplus. Their structures were proposed based on 1D and 2D NMR spectroscopic data analysis. These diterpenoids were evaluated for potential anti-inflammatory activity in a lipopolysaccharide-stimulated mouse macrophage cellular model. Compounds3,4,11,13, and16displayed moderate inhibitory effects on NO inhibition, with IC50values ranging from 29.9 to 38.3 μM.