Genetics of anaplastic large cell lymphoma.
Genetics of anaplastic large cell lymphoma.
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DOI：
10.3109/10428194.2015.1064530
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发表时间：
2016
影响因子：
2.6
通讯作者：
Feldman AL
中科院分区：
文献类型：
--
作者：
Zeng Y;Feldman AL
Anaplastic large cell lymphoma (ALCL) comprises a group of T-cell non-Hodgkin lymphomas unified by common morphologic and immunophenotypic characteristics, but with a spectrum of clinical presentations and behaviors. Early identification of anaplastic lymphoma kinase (ALK) gene rearrangements in some ALCLs led to recognition of ALK as an important diagnostic and prognostic biomarker, and a key driver of ALCL pathobiology. Rearrangements and other genetic abnormalities of ALK subsequently were identified in diverse other human malignancies. Recent clinical, pathologic, and genetic data have begun to shed light on ALK-negative ALCLs, revealing significant heterogeneity within this more ill-defined entity.
