Influence of Enteral Feedings on Phenytoin Sodium Absorption from Capsules
Influence of Enteral Feedings on Phenytoin Sodium Absorption from Capsules
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肠内喂养对苯妥英钠胶囊吸收的影响
DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
R. Iacono
中科院分区：
文献类型：
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作者：
Lyn Y. Nishimura;E. Armstrong;P. Plezia;R. Iacono
The influence of enteral feedings (with Ensure) on the absorption of phenytoin sodium from capsules was studied. Six healthy adult volunteers were given a single dose of phenytoin capsules 400 mg po on two occasions. Blood specimens were collected for 48 hours after each dose. In a randomized, crossover fashion, each subject completed the following two phases: (1) phenytoin without enteral feedings, and (2) concomitant enteral feedings before phenytoin and continued at 100 ml/h for ten hours. The areas under the concentration versus time curves from 0-48 hours (AUCo-48) were not significantly different between the two phases (p > 0.5). The percent relative bioavailability of phenytoin with enteral feedings was 101.7 percent. This study suggests that enteral feedings do not affect the serum concentrations of phenytoin after a single dose given in capsule form.
