ANTI-AIDS AGENTS .9. SUBEROSOL, A NEW C31 LANOSTANE-TYPE TRITERPENE AND ANTI-HIV PRINCIPLE FROM POLYALTHIA-SUBEROSA
ANTI-AIDS AGENTS .9. SUBEROSOL, A NEW C31 LANOSTANE-TYPE TRITERPENE AND ANTI-HIV PRINCIPLE FROM POLYALTHIA-SUBEROSA
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DOI：
10.1021/np50097a017
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发表时间：
1993-07-01
影响因子：
5.1
通讯作者：
LEE, KH
中科院分区：
文献类型：
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作者：
LI, HY;SUN, NJ;LEE, KH
一种新的 C31 羊毛甾烷型三萜，被命名为 suberosol [1]，已从 Polyalthia suberosa 中分离出来，作为一种抗 HIV 成分。根据光谱证据，该结构被定性为 24-亚甲基-7,9(11)-二烯-3β,15α-二醇（suberosol）[1]。发现化合物 1 在 H9 淋巴细胞中表现出抗 HIV 复制活性，EC50 为 3 μg/ml。
A new C31 lanostane-type triterpene, assigned the trivial name suberosol [1], has been isolated from Polyalthia suberosa as an anti-HIV principle. The structure has been characterized as 24-methylenelanost-7,9(11)-diene-3beta,15alpha-diol (suberosol) [1], based on spectroscopic evidence. Compound 1 was found to show anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 3 mug/ml.