MICROPARTICULATE ABSORPTION FROM THE RAT INTESTINE
MICROPARTICULATE ABSORPTION FROM THE RAT INTESTINE
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DOI：
10.1016/0168-3659(94)90079-5
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发表时间：
1994-03-01
影响因子：
10.8
通讯作者：
OHAGAN, DT
中科院分区：
文献类型：
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作者：
JENKINS, PG;HOWARD, KA;OHAGAN, DT
将一系列荧光聚苯乙烯微粒（0.15、0.5、1.0、3.0和10.0 μ m）经尿道内给予Wistar大鼠，以提供微粒吸收水平的评估。将用于上级肠系膜淋巴管插管和派尔集合淋巴结和肠系膜淋巴结去除的外科手术与灵敏的流式细胞术测定相结合，可以量化穿过肠道的微粒吸收。吸收发生在5分钟后，是随时间变化的，对于所有尺寸的微粒，在研究的时间段内。发现0.5 μ m的微粒被发热斑吸收的数量显著增加（P
A range of fluorescent polystyrene microparticles (0.15, 0.5, 1.0, 3.0 and 10.0 mu m) were administered intraduodenally to Wistar rats to provide an assessment of the levels of absorption of microparticles. Coupling a surgical procedure for the cannulation of the superior mesenteric lymph duct and the removal of Peyer's patches and mesenteric lymph nodes, with a sensitive flow cytometric assay it was possible to quantify microparticle absorption across the intestine. Absorption occurred after 5 min and was temporally variable, for all sizes of microparticles, over the time period studied. The 0.5-mu m microparticles were found to be absorbed in significantly greater numbers to the Fever's patches (P