Impact of metabolic syndrome on the incidence of type 2 diabetes in middle-aged Japanese individuals with impaired insulin secretion: the Saku study
Impact of metabolic syndrome on the incidence of type 2 diabetes in middle-aged Japanese individuals with impaired insulin secretion: the Saku study
复制标题
代谢综合征对胰岛素分泌受损的中年日本人 2 型糖尿病发病率的影响：Saku 研究
DOI：
10.1007/s13340-016-0287-6
复制
发表时间：
2017
影响因子：
2.2
通讯作者：
Sakaguchi S
中科院分区：
文献类型：
--
作者：
Morimoto A;Tatsumi Y;Sonoda N;Miyamatsu N;Shimoda T;Sakaguchi S
AimsTo评估代谢综合征（MetS）对2型糖尿病发病率的影响，在中年日本人胰岛素分泌受损（IIS）.MethodsThis队列研究包括1,702名40-59岁的人没有糖尿病在基线谁进行了全面的体检之间的2008年4月和2009年3月在佐久中央医院。参与者根据他们的IIS和胰岛素抵抗（IR）状态[正常，孤立IR（i-IR）或孤立IIS（i-IIS）]和MetS（存在或不存在）进行分类。随访至2014年3月。2型糖尿病的定义是基于空腹和2小时后负荷血糖浓度和接受药物治疗的diabetes.ResultsDuring 7,572人年的随访，92人发展为2型糖尿病。在正常无MetS、正常伴MetS、i-IR无MetS、i-IR伴MetS、i-IIS无MetS和i-IIS伴MetS组中，2型糖尿病的发病率（/1，000人-年）分别为5.3、3.7、11.3、24.7、16.7和59.5。相对于正常无MetS组，正常MetS组、i-IR伴MetS组和i-IIS伴MetS组2型糖尿病的多变量校正风险比（HR）和95%置信区间（CI）分别为0.52（0.12-2.25）、3.78（1.93-7.42）和7.94（3.96-15.91）。此外，在i-IIS组中观察到MetS与2型糖尿病的正相关性[HR（95% CI）3.56（1.88-6.73）]，但在正常和i-IR组中未观察到。
AimsTo assess the impact of metabolic syndrome (MetS) on the incidence of type 2 diabetes in middle-aged Japanese individuals with impaired insulin secretion (IIS).MethodsThis cohort study included 1,702 individuals aged 40–59 without diabetes at baseline who underwent a comprehensive medical check-up between April 2008 and March 2009 at Saku Central Hospital. Participants were classified according to their IIS and insulin resistance (IR) status [normal, isolated IR (i-IR), or isolated IIS (i-IIS)] and MetS (presence or absence). They were followed up until March 2014. Type 2 diabetes was defined based on fasting and 2-h post-load plasma glucose concentrations and by the receipt of medical treatment for diabetes.ResultsDuring 7,572 person-years of follow-up, 92 individuals developed type 2 diabetes. The incidence rates (/1,000 person-years) for type 2 diabetes in the normal without MetS, normal with MetS, i-IR without MetS, i-IR with MetS, i-IIS without MetS, and i-IIS with MetS groups were 5.3, 3.7, 11.3, 24.7, 16.7, and 59.5, respectively. The multivariable-adjusted hazard ratios (HRs) and 95 % confidence intervals (CIs) for type 2 diabetes in the normal with MetS, i-IR with MetS, and i-IIS with MetS groups, relative to the normal without MetS group, were 0.52 (0.12–2.25), 3.78 (1.93–7.42), and 7.94 (3.96–15.91), respectively. Additionally, a positive association of MetS with type 2 diabetes was observed in the i-IIS group [HR (95 % CI) 3.56 (1.88–6.73)] but not in the normal and i-IR groups.ConclusionsThe prevention of MetS is important, particularly in individuals with low insulin secretion.