Hostility and Cellular Aging in Men from the Whitehall II Cohort
Hostility and Cellular Aging in Men from the Whitehall II Cohort
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DOI：
10.1016/j.biopsych.2011.08.020
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发表时间：
2012-05-01
影响因子：
10.6
通讯作者：
Steptoe, Andrew
中科院分区：
文献类型：
--
作者：
Brydon, Lena;Lin, Jue;Steptoe, Andrew
背景：敌意与年龄相关疾病和死亡的风险显著增加有关，但涉及的病理生理学机制尚不清楚。在这里，我们调查了敌意可能通过促进细胞衰老而影响健康的假设。方法：我们测试了白厅II队列中434名男性和女性的愤世嫉俗敌意与两个已知的细胞老化标志-白细胞端粒长度(TL)和白细胞端粒酶活性(TA)的关系。结果：高度敌意男性的白细胞端粒长度显著短于低敌意男性。他们的白细胞TA也升高，与低敌意个体相比，短TL和高TA的可能性显著增加。结论：由于已知端粒酶通过合成端粒DNA重复来抵消端粒缩短，特别是在端粒缩短的情况下，TA升高可能代表高度敌意个体的代偿反应。男性的敌意与疾病之间的关系比女性更强，而且男性的预期寿命通常比女性短。我们的发现表明，端粒磨损可能代表了一种新的机制，介导了敌意对男性健康的有害影响。
Background: Hostility is associated with a significantly increased risk of age-related disease and mortality, yet the pathophysiological mechanisms involved remain unclear. Here we investigated the hypothesis that hostility might impact health by promoting cellular aging.Methods: We tested the relationship between cynical hostility and two known markers of cellular aging, leukocyte telomere length (TL) and leukocyte telomerase activity (TA), in 434 men and women from the Whitehall II cohort.Results: High-hostile men had significantly shorter leukocyte TL than their low-hostile counterparts. They also had elevated leukocyte TA, with a significantly increased likelihood of having both short TL and high TA, compared with low-hostile individuals.Conclusions: Because telomerase is known to counteract telomere shortening by synthesizing telomeric DNA repeats, particularly in the context of shortened telomeres, heightened TA might represent a compensatory response in high-hostile individuals. The relationship between hostility and disease is stronger in men than in women, and men generally have a shorter life expectancy than women. Our findings suggest that telomere attrition might represent a novel mechanism mediating the detrimental effects of hostility on men's health.