Bromomaleimides: new reagents for the selective and reversible modification of cysteine
Bromomaleimides: new reagents for the selective and reversible modification of cysteine
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DOI：
10.1039/b915136b
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发表时间：
2009-01-01
影响因子：
4.9
通讯作者：
Baker, James R.
中科院分区：
文献类型：
--
作者：
Tedaldi, Lauren M.;Smith, Mark E. B.;Baker, James R.
溴代马来酰亚胺与半胱氨酸快速且选择性地反应，得到硫代马来酰亚胺，硫代马来酰亚胺可以用膦裂解以再生半胱氨酸或用碱处理以得到脱氢丙氨酸。
Bromomaleimides react rapidly and selectively with cysteine to afford thiomaleimides which can be cleaved with a phosphine to regenerate the cysteine or treated with a base to afford dehydroalanine.