Chemical and Toxicological Investigations of a Previously Unknown Poisonous European Mushroom Tricholoma terreum
Chemical and Toxicological Investigations of a Previously Unknown Poisonous European Mushroom Tricholoma terreum
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对以前未知的有毒欧洲蘑菇土口蘑的化学和毒理学研究
DOI：
10.1002/chem.201400226
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发表时间：
2014-06-02
影响因子：
4.3
通讯作者：
Liu, Ji-Kai
中科院分区：
文献类型：
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作者：
Yin, Xia;Feng, Tao;Liu, Ji-Kai
野生蘑菇的消费和销售传统已将注意力集中在真菌毒性上，这已成为一个全球性问题。在目前的研究中，我们描述了毒素发现在一个以前未知的有毒的欧洲蘑菇三角口蘑。从毒蘑菇T. terreum的子实体中分离到15个新的三萜类化合物a - f（1-6）和皂苷类化合物h - p（8-16）。terreolides a - c（1-3）具有独特的5/6/7三螺酮体系，而terreolides D-F（4-6）具有前所未有的碳骨架。香菇中两种丰富的化合物皂苷b(7)和皂苷m（13）表现出急性毒性，小鼠口服时LD50值分别为88.3和63.7mgkg-1。这两种化合物都能增加小鼠血清肌酸激酶水平，表明T. terreum可能是蘑菇中毒的原因，最终导致横纹肌溶解。
The established tradition of consuming and marketing wild mushrooms has focused attention on mycotoxicity, which has become a global issue. In the present study, we describe the toxins found in a previously unknown poisonous European mushroom Tricholoma terreum. Fifteen new triterpenoids terreolidesA-F (1-6) and saponaceolidesH-P (8-16) were isolated from the fruiting bodies of the toxic mushroom T. terreum. TerreolidesA-C (1-3) possessed a unique 5/6/7 trioxaspiroketal system, whereas terreolides D-F (4-6) possessed an unprecedented carbon skeleton. Two abundant compounds in the mushroom, saponaceolideB (7) and saponaceolideM (13), displayed acute toxicity, with LD50 values of 88.3 and 63.7mgkg-1 when administered orally in mice. Both compounds were found to increase serum creatine kinase levels in mice, indicating that T. terreum may be the cause of mushroom poisoning ultimately leading to rhabdomyolysis.