Strong associations and moderate predictive value of early symptoms for SARS-CoV-2 test positivity among healthcare workers, the Netherlands, March 2020
Strong associations and moderate predictive value of early symptoms for SARS-CoV-2 test positivity among healthcare workers, the Netherlands, March 2020
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DOI：
10.2807/1560-7917.es.2020.25.16.2000508
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发表时间：
2020-04-23
期刊：
影响因子：
19
通讯作者：
Wertheim, Heiman
中科院分区：
文献类型：
--
作者：
Tostmann, Alma;Bradley, John;Wertheim, Heiman
对有轻度症状的医护人员（n=803）进行了严重急性呼吸综合征冠状病毒2（SARS-COV-2）检测（n =90例阳性），并要求他们填写症状问卷。嗅觉丧失、肌肉疼痛、眼痛、全身不适、头痛、极度疲劳和发热与阳性相关。基于这些症状的预测模型显示出中等判别价值（敏感性：91.2%;特异性：55.6%）。虽然我们的模型在没有分子确认的情况下不能证明推定的SARS-CoV-2诊断是正确的，但它有助于有针对性的筛查策略。
Healthcare workers (n=803) with mild symptoms were tested for severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) (n =90 positive) and asked to complete a symptom questionnaire. Anosmia, muscle ache, ocular pain, general malaise, headache, extreme tiredness and fever were associated with positivity. A predictive model based on these symptoms showed moderate discriminative value (sensitivity: 91.2%; specificity: 55.6%). While our models would not justify presumptive SARS-CoV-2 diagnosis without molecular confirmation, it can contribute to targeted screening strategies.