fMR1 data predict individual differences of behavioral effects of nicotine:: A partial least square analysis
fMR1 data predict individual differences of behavioral effects of nicotine:: A partial least square analysis
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DOI：
10.1162/jocn.2007.19.4.658
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发表时间：
2007-04-01
影响因子：
3.2
通讯作者：
Thiel, C. M.
中科院分区：
文献类型：
--
作者：
Giessing, C.;Fink, G. R.;Thiel, C. M.
视觉空间注意力的重新定向可以通过比较有效和无效提示目标的反应时间（“有效性效应”）来研究。胆碱能激动剂尼古丁会降低后顶叶皮质的有效性和神经活动。尼古丁对非吸烟者的行为影响较弱，有人认为尼古丁暴露前基线行为的差异可能会影响尼古丁的效果。这项研究调查了安慰剂下与重新定向相关的神经活动的个体差异是否可以用来预测个体尼古丁的影响。个体尼古丁效应被定义为尼古丁作用下的行为效应，无法通过安慰剂下的行为数据来预测。在磁共振成像扫描仪内执行提示目标检测任务之前，给 15 名不吸烟受试者服用安慰剂或尼古丁口香糖（2 毫克）。偏最小二乘分析的结果表明，安慰剂下的神经数据可用于预测尼古丁对个体行为的影响。左后扣带皮层、右上顶叶皮层、右背内侧前额叶皮层和左腹侧内侧前额叶皮层的神经活动对这一预测有显着贡献。我们得出的结论是，尼古丁对注意力重新定向的影响取决于安慰剂下与重新定向相关的神经活动的个体差异，并表明功能磁共振成像数据可以有助于预测个体药物效应。
Reorienting of visuospatial attention can be investigated by comparing reaction times to validly and invalidly cued targets ("validity effect"). The cholinergic agonist nicotine reduces the validity effect and neural activity in the posterior parietal cortex. Behavioral effects of nicotine in nonsmokers are weak and it has been suggested that differences in baseline behavior before nicotine exposure may influence the effect of nicotine. This study investigates whether individual differences in reorienting-related neural activity under placebo may be used to predict individual nicotine effects. Individual nicotine effects are defined as the behavioral effects under nicotine that cannot be predicted by the behavioral data under placebo. Fifteen nonsmoking subjects were given either placebo or nicotine gum (2 mg) prior to performing a cued target detection task inside a magnetic resonance imaging scanner. The results of a partial least square analysis suggest that neural data under placebo can be used to predict individual behavioral effects of nicotine. Neural activity in the left posterior cingulate cortex, the right superior parietal cortex, the right dorsal medial prefrontal cortex, and the left ventral medial prefrontal cortex significantly contributes to that prediction. We conclude that nicotine effects on reorienting attention depend on individual differences in reorienting-related neural activity under placebo and suggest that functional magnetic resonance imaging data can contribute to the prediction of individual drug effects.